ArticleBiochemical and biophysical research communications2014
The control of lipid metabolism by mRNA splicing in Drosophila.
Article in Biochemical and biophysical research communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.Nature communications · 2026Article
- glorund functions in themicroPublication biology · 2026Article
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- The regulation of triglyceride storage bymicroPublication biology · 2025Article
- Regulation of Alternative Splicing of Lipid Metabolism Genes in Sepsis-Induced Liver Damage by RNA-Binding Proteins.Inflammation · 2024Article
- The regulation of carnitine palmitoyltransferase 1 (Biochemistry and biophysics reports · 2024Article
- Knockdown of carnitine palmitoyltransferase I (CPT1) reduces fat body lipid mobilization and resistance to starvation in the insect vectorFrontiers in physiology · 2023Article
- Expression of a constitutively active insulin receptor in Drosulfakinin (Dsk) neurons regulates metabolism and sleep inBiochemistry and biophysics reports · 2022Article
- RNA-seq reveals insights into molecular mechanisms of metabolic restoration via tryptophan supplementation in low birth weight piglet model.Journal of animal science · 2022Article
- The regulation of lipid and carbohydrate storage by the splicing factor genemicroPublication biology · 2022Article
- The heterogeneous nuclear ribonucleoprotein (hnRNP) glorund functions in theBiochemistry and biophysics reports · 2021Article
- Variation in sleep and metabolic function is associated with latitude and average temperature inEcology and evolution · 2018Article
- The splicing factor transformer2 (tra2) functions in the Drosophila fat body to regulate lipid storage.Biochemical and biophysical research communications · 2018Article
- Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle.BMC genomics · 2017Article
- translin Is Required for Metabolic Regulation of Sleep.Current biology : CB · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The storage of lipids is an evolutionarily conserved process that is important for the survival of organisms during shifts in nutrient availability. Triglycerides are stored in lipid droplets, but the mechanisms of how lipids are stored in these structures are poorly understood. Previous in vitro RNAi screens have implicated several components of the spliceosome in controlling lipid droplet formation and storage, but the in vivo relevance of these phenotypes is unclear. In this study, we identify specific members of the splicing machinery that are necessary for normal triglyceride storage in the Drosophila fat body. Decreasing the expression of the splicing factors U1-70K, U2AF38, U2AF50 in the fat body resulted in decreased triglyceride levels. Interestingly, while decreasing the SR protein 9G8 in the larval fat body yielded a similar triglyceride phenotype, its knockdown in the adult fat body resulted in a substantial increase in lipid stores. This increase in fat storage is due in part to altered splicing of the gene for the β-oxidation enzyme CPT1, producing an isoform with less enzymatic activity. Together, these data indicate a role for mRNA splicing in regulating lipid storage in Drosophila and provide a link between the regulation of gene expression and lipid homeostasis.
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