ArticleBehavioural brain research2014
Sleep deprivation impairs performance in the 5-choice continuous performance test: similarities between humans and mice.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors.The international journal of neuropsychopharmacology · 2017Trial
- Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species.Neuropharmacology · 2017Trial
- Sex differences in task engagement and lapse rate during reward learning.Oxford open neuroscience · 2026Article
- Exploring the connection between the Mitochondrial DNA and the Circadian Rhythm: Insights into Mitochondrial Biogenesis and its Dynamics.Molecular biology reports · 2025Review
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- Proceedings of the 2022 annual meeting of the Fetal Alcohol Spectrum Disorders study group.Alcohol (Fayetteville, N.Y.) · 2023Article
- Article
- Administration of growth hormone ameliorates adverse effects of total sleep deprivation.Metabolic brain disease · 2023Article
- Impulsivity in Bipolar Disorder: State or Trait?Brain sciences · 2022Review
- Preclinical Evaluation of Attention and Impulsivity Relevant to Determining ADHD Mechanisms and Treatments.Current topics in behavioral neurosciences · 2022Article
- Ambient Stimuli Perpetuate Nighttime Sleep Disturbances in Hospital Patients With TBI.Biological research for nursing · 2021Observational
- Convergent observations of MK-801-induced impairment in rat 5C-CPT performance across laboratories: reversal with a DPsychopharmacology · 2021Article
- Excessive Daytime Sleepiness and Safety Performance: Comparing Proactive and Reactive Approaches.The international journal of occupational and environmental medicine · 2020Article
- Performance on the mouse vibration actuating search task is compromised by sleep deprivation.Journal of neurophysiology · 2020Article
- Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT.Bipolar disorders · 2020Article
- Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids.Journal of neuroendocrinology · 2020Review
- Injury, Sleep, and Functional Outcome in Hospital Patients With Traumatic Brain Injury.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2019Article
- Effects of circadian misalignment on sleep in mice.Scientific reports · 2018Article
- Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia.Translational psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Several groups undergo extended periods without sleep due to working conditions or mental illness. Such sleep deprivation (SD) can deleteriously affect attentional processes and disrupt work and family functioning. Understanding the biological underpinnings of SD effects may assist in developing sleep therapies and cognitive enhancers. Utilizing cross-species tests of attentional processing in humans and rodents would aid in mechanistic studies examining SD-induced inattention. We assessed the effects of 36h of: (1) Total SD (TSD) in healthy male and female humans (n=50); and (2) REM SD (RSD) in male C57BL/6 mice (n=26) on performance in the cross-species 5-choice continuous performance test (5C-CPT). The 5C-CPT includes target trials on which subjects were required to respond and non-target trials on which subjects were required to inhibit from responding. TSD-induced effects on human psychomotor vigilance test (PVT) were also examined. Effects of SD were also examined on mice split into good and poor performance groups based on pre-deprivation scores. In the human 5C-CPT, TSD decreased hit rate and vigilance with trend-level effects on accuracy. In the PVT, TSD slowed response times and increased lapses. In the mouse 5C-CPT, RSD reduced accuracy and hit rate with trend-level effects on vigilance, primarily in good performers. In conclusion, SD induced impaired 5C-CPT performance in both humans and mice and validates the 5C-CPT as a cross-species translational task. The 5C-CPT can be used to examine mechanisms underlying SD-induced deficits in vigilance and assist in testing putative cognitive enhancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.