ArticleBlood transfusion = Trasfusione del sangue2014
The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units.
Article in Blood transfusion = Trasfusione del sangue, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.JPEN. Journal of parenteral and enteral nutrition · 2016Trial
- Red blood cell transfusion frequency and the risk and severity of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.BMC pediatrics · 2025Article
- Fluoride Ingestion Induces Formation of Unusual Macromolecular Complexes in Gut Lumen Which Retard Absorption of Essential Minerals and Trace Elements by Chelation.Biological trace element research · 2025Article
- The Effects of Glutathione Monoethyl Ester on Different Biochemical, Oxidant, and Antioxidant Levels During Storage in Leukoreduced Red Blood Cells.Advanced biomedical research · 2024Article
- Variability of extracellular vesicle release during storage of red blood cell concentrates is associated with differential membrane alterations, including loss of cholesterol-enriched domains.Frontiers in physiology · 2023Article
- Evaluation of selected hematological, biochemical and oxidative stress parameters in stored canine CPDA-1 whole blood.BMC veterinary research · 2022Article
- Using redox potential as a feasible marker for banked blood quality and the state of oxidative stress in stored red blood cells.Journal of clinical laboratory analysis · 2021Article
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- Review
- ICP-MS trace element analysis in serum and whole blood.PloS one · 2020Article
- Pseudomonas poae-Associated Fatal Septic Transfusion Reaction, Peoria, Illinois, USA, 2017.Emerging infectious diseases · 2019Article
- Role of redox iron towards an increase in mortality among patients: a systemic review and meta-analysis.Blood research · 2019Review
- Early Oxidative Stress Response in Patients with Severe Aortic Stenosis Undergoing Transcatheter and Surgical Aortic Valve Replacement: A Transatlantic Study.Oxidative medicine and cellular longevity · 2019Observational
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions.Scientific reports · 2017Article
- Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy.Urologic oncology · 2017Article
- On the source of the non-transferrin-bound iron which accumulates in packed red blood cell units during storage.Blood transfusion = Trasfusione del sangue · 2014Article
- Transfusion related morbidity in premature babies: Possible mechanisms and implications for practice.World journal of clinical pediatrics · 2014Review
- The involvement of cation leaks in the storage lesion of red blood cells.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReceipt of blood transfusions is associated with the major consequences of prematurity such as bronchopulmonary dysplasia. Transfusion-mediated (iron-induced) oxidative damage, coupled with the limited ability of the premature baby to deal with enhanced iron and oxidative load may contribute to this. Adverse effects of transfusion may be related to duration of storage. This study examined the influence of storage on iron and oxidative status in paediatric packed red blood cell units. MATERIALS AND
methodsPaediatric packed red blood cell units were sampled 3 days post-donation, then at 7 days and weekly until day 35. The extracellular medium was separated and the following measured: total iron concentration, total iron binding capacity, non-transferrin-bound iron, haemoglobin, total and reduced ascorbate, glutathione and malondialdehyde.
resultsMeasurable total and non-transferrin bound iron were present in the extracellular fluid of paediatric packs on day 3. Both parameters rose almost linearly to maximal values at 35 days. Haemoglobin and malondialdehyde levels rose gradually from day 3 to day 21, then more steeply to day 35. Ascorbate existed mainly in the oxidised form and fell rapidly towards the end of storage. Intracellular GSH fell throughout the period of storage. Strong correlations existed between biomarkers of oxidative damage and iron parameters. DISCUSSION: These data suggest that iron released following the initial preparation of packed red blood cell units may derive from free radical-mediated oxidative damage to the red blood cells and haemoglobin, rather than from extracellular haemoglobin. Iron continues to be released during storage as antioxidant protection declines. A cycle of free radical-mediated damage may initiate and then further exacerbate iron release during storage which, in turn, may mediate further free radical-mediated cellular damage. The potential consequences to recipients of older stored blood may be significant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.