Evidence map›Paper›PMID 24332821›Full record

ArticleThe Journal of pediatrics2014

Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy.

Lina F Chalak, Pablo J Sánchez, Beverley Adams-Huet, Abbot R Laptook, Roy J Heyne, Charles R Rosenfeld

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 4 pooled it
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 4 syntheses or guidelines pooled it, 256 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Role of astrocytes in the pathogenesis of perinatal brain injury.Molecular medicine (Cambridge, Mass.) · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Role of Netrin-1 in staging hypoxic ischemic encephalopathy.Revista da Associacao Medica Brasileira (1992) · 2025
    Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lina F ChalakDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: lina.chalak@utsouthwestern.edu.
Pablo J SánchezDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Beverley Adams-HuetDepartment of Clinical Sciences and Statistics, University of Texas Southwestern Medical Center, Dallas, TX.
Abbot R LaptookDepartment of Pediatrics, Brown University, Women & Infants Hospital of Rhode Island, Providence, RI.
Roy J HeyneDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Charles R RosenfeldDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
The University of Texas Southwestern Medical Center · USBrown University · US

Funding

Cerebrovascular Dysfunction in Newborns with HIE during Hypothermia and RewarmingK23HD069521 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI CHALAK, LINA F · 2012 to 2014
$368k
NICHD NIH HHS K23 HD069521NICHD NIH HHS K23HD069521
6 · The paper itself

Abstract

objectiveTo evaluate serum neuronal and inflammatory biomarkers to determine whether measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic encephalopathy (HIE), whether serial measurements differ with hypothermia-rewarming, and whether biomarkers correlate with neurological outcomes. STUDY

designThis is a prospective cohort of inborn term newborns with varying degrees of HIE by neurological assessment. Neuronal glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase L1, and inflammatory cytokines were measured in serum from umbilical artery at 6-24, 48, 72, and 78 hours of age. Neurodevelopmental outcomes (Bayley Scales of Infant and Toddler Development-III scales) were performed at 15-18 months.

resultsTwenty neonates had moderate (n = 17) or severe (n = 3) HIE and received hypothermia; 7 had mild HIE and were not cooled. At birth, serum GFAP and ubiquitin carboxyl-terminal hydrolase L1 increased with the severity of HIE (P < .001), and serial GFAP remained elevated in neonates with moderate to severe HIE. Interleukin (IL)-6, IL-8, and vascular endothelial growth factor were greater at 6-24 hours in moderate to severe vs mild HIE (P < .05). The serial values were unaffected by hypothermia-rewarming. Elevated GFAP, IL-1, IL-6, IL-8, tumor necrosis factor, interferon, and vascular endothelial growth factor at 6-24 hours were associated with abnormal neurological outcomes.

conclusionsThe severity of the hypoxic-ischemic injury can be stratified at birth because elevated neuronal biomarkers in cord serum correlated with severity of HIE and outcomes.

Indexed as

Hypothermia, InducedAlanine TransaminaseApgar ScoreAspartate AminotransferasesBiomarkersBrainCerebral PalsyCreatinineCytokinesDevelopmental DisabilitiesElectroencephalographyFemaleFetal BloodGlial Fibrillary Acidic ProteinHumansHypoxia-Ischemia, BrainAlanine TransaminaseAspartate AminotransferasesBiomarkersCreatinineCytokinesGlial Fibrillary Acidic ProteinUbiquitin carboxyl-Terminal Hydrolase L-1, humanUbiquitin ThiolesteraseVascular Endothelial Growth Factor A

Identifiers

PMID24332821
PMCPMC4006934
OpenAlexW2026899473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.