Evidence map›Paper›PMID 24332790›Full record

ArticleDrug and alcohol dependence2014

Sex differences in the effects of estradiol in the nucleus accumbens and striatum on the response to cocaine: neurochemistry and behavior.

Jennifer A Cummings, Lakshmikripa Jagannathan, Lisa R Jackson, Jill B Becker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jennifer A CummingsMolecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States.
Lakshmikripa JagannathanMolecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States.
Lisa R JacksonDepartment of Psychology, Schoolcraft College, Livonia, MI 48152, United States.
Jill B BeckerMolecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, United States; Department of Psychology, University of Michigan, Ann Arbor, MI 48109, United States; Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address: jbbecker@umich.edu.
University of Michigan–Ann Arbor · USSchoolcraft College · US

Funding

GENDER DIFFERENCES IN DRUG ABUSER01DA012677 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BECKER, JILL B. · 2000 to 2013
$3.6M
Rapid Effects of Estradiol in the BrainR01NS048141 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BECKER, JILL B · 2004 to 2007
$1.3M
Protective benefits of maternal behavior on susceptibility for drug abuseR21DA027924 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BECKER, JILL B. · 2010 to 2011
$390k
NIDA NIH HHS R01 DA012677NIDA NIH HHS R21 DA027924NINDS NIH HHS R01 NS048141
6 · The paper itself

Abstract

backgroundFemales exhibit more rapid escalation of cocaine use and enhanced cocaine-taking behavior as compared to males. While ovarian hormones likely play a role in this increased vulnerability, research has yet to examine the role of estradiol in affecting the behavioral and neurological response to cocaine in a brain region- and sex-specific way.

methodsFirst, we examined stereotypy and locomotor sensitization after repeated cocaine administration (10 mg/kg i.p.) in intact (SHAM) and castrated (CAST) males, and ovariectomized (OVX) females treated with 5 μg estradiol benzoate (EB) or vehicle (OIL). Next, we used in vivo microdialysis to examine the effects of acute EB treatment on cocaine-induced DA in the regions mediating the display of these behaviors (i.e., the dorsolateral striatum, DLS; and the nucleus accumbens, NAc; respectively).

resultsWe find that EB enhances sensitization of cocaine-induced stereotypy in OVX females after 12 days of cocaine treatment, and after a 10-day withdrawal. Similarly, the OVX/EB females show enhanced locomotor sensitization compared to the other three groups on the same days. Using in vivo microdialysis to assess the neurochemical response, we find that EB rapidly enhances cocaine-induced DA in DLS dialysate of OVX females but not CAST males, and has no effect in NAc of either sex.

conclusionsWith these experiments, we show that there are sex differences in the effects of estradiol to preferentially enhance the response to cocaine in the DLS over the NAc in females, which may contribute to the preferential sensitization of stereotypy in females.

Indexed as

Sex CharacteristicsAnimalsCocaineCocaine-Related DisordersCorpus StriatumEstradiolFemaleMaleMicrodialysisMotor ActivityNucleus AccumbensRatsRats, Sprague-DawleyCocaineEstradiolBehavioral sensitizationDopamineDrug abuseMicrodialysisSex differences

Identifiers

PMID24332790
PMCPMC3947194
OpenAlexW2085514332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.