Observational studyJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2014
Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.
Observational study in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of hypertonic saline and/or carbocisteine on sputum rheology in bronchiectasis: CLEAR-EME.ERJ open research · 2026Article
- Host- and microbial-mediated mucin degradation differentially shape Pseudomonas aeruginosa physiology and gene expression.PLoS pathogens · 2025Article
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- Cystic Fibrosis Airway Mucus Hyperconcentration Produces a Vicious Cycle of Mucin, Pathogen, and Inflammatory Interactions that Promotes Disease Persistence.American journal of respiratory cell and molecular biology · 2022Article
- Inter-individual Variation in Receptor Expression Influences MERS-CoV Infection and Immune Responses in Airway Epithelia.Frontiers in public health · 2021Article
- Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis.American journal of respiratory and critical care medicine · 2020Article
- The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells.Journal of aerosol medicine and pulmonary drug delivery · 2019Article
- An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.American journal of respiratory and critical care medicine · 2019Article
- Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH.The European respiratory journal · 2018Article
- Intracellular Processing of Human Secreted Polymeric Airway Mucins.Annals of the American Thoracic Society · 2018Review
- MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.Chest · 2017Article
- The Mucus Barrier to Inhaled Gene Therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Review
- Biosynthesis of the polymeric gel-forming mucin MUC5B.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Cystic fibrosis: an inherited disease affecting mucin-producing organs.The international journal of biochemistry & cell biology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is conflicting evidence about the importance of airway mucins (MUC5AC and MUC5B) in determining physical properties of sputum in cystic fibrosis (CF). We studied the effects of endogenous degradation of mucins on CF sputum elasticity and apparent mucin concentrations.
methodsElastic shear moduli (G') and mucin concentrations in sputum of 12 CF patients were measured before and after incubation at 37°C for 60min.
resultsG' fell from a median of 5.98 to 4.70Pa (p=0.01). There were significant falls in MUC5AC (8.2 to 5.2μg/ml, p=0.02) and MUC5B (17.3 to 12.5μg/ml, p=0.02) over the same period, and associated decrease in molecular weight and size.
conclusionsSputum is not inert and degradation reduces apparent mucin concentrations and sputum elasticity. Even if care is taken to process samples rapidly, sputum may therefore differ from secretions retained in airways. Previous studies may have underestimated the role of mucins in CF sputum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.