ReviewTrends in immunology2014
BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.
Review in Trends in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- A dynamic gene regulatory code drives synaptic development of hippocampal granule cells.Science advances · 2025Article
- Co-expression of bovine leukemia virus and bovine foamy virus-derived miRNAs in naturally infected cattle.Microbiology spectrum · 2025Article
- Inferring gene regulatory networks by hypergraph generative model.Cell reports methods · 2025Article
- IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023Review
- Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease.Frontiers in immunology · 2023Article
- Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response.Journal of immunology research · 2022Review
- Article
- Role ofInternational journal of molecular sciences · 2021Article
- Transcriptional Regulation of Genes by Ikaros Tumor Suppressor in Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2020Review
- Transcriptomic analysis of early B-cell development in the chicken embryo.Poultry science · 2019Article
- BATF-Interacting Proteins Dictate Specificity in Th Subset Activity.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia.BMC cancer · 2019Article
- Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress.Oxidative medicine and cellular longevity · 2019Review
- Article
- Apoptosis in inner ear sensory hair cells.Journal of otology · 2017Review
- Article
- Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia.Blood · 2017Article
- Article
- EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
At the pre-B cell receptor (BCR) checkpoint, developing pre-B cells are selected for successful rearrangement of V(H)-DJ(H) gene segments and expression of a pre-BCR. Reduced stringency at this checkpoint may obstruct the B cell repertoire with nonfunctional B cell clones. Earlier studies have described that activation of B cell lymphoma/leukemia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the checkpoint. This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint. Here, we discuss the antagonism between BCL6 and BACH2 during early B cell development, as well as its implications in both repertoire selection and counter-selection of premalignant clones for leukemia suppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.