Evidence map›Paper›PMID 24332482›Full record

ReviewMolecular immunology2014

Contributions of B cells to lupus pathogenesis.

Allison Sang, Ying-Yi Zheng, Laurence Morel

Abstract readReview
In one paragraph

Review in Molecular immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. T cell help in the autoreactive germinal center.Scandinavian journal of immunology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020
    Review
  17. B cell-intrinsic TLR9 expression is protective in murine lupus.The Journal of clinical investigation · 2020
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Allison SangDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
Ying-Yi ZhengDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.
Laurence MorelDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: morel@ufl.edu.

Funding

Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
B Cell Development Defects in Murine LupusR01AI058150 · NIAID · UNIVERSITY OF FLORIDA · PI MOREL, LAURENCE · 2004 to 2014
$3.7M
NIAID NIH HHS R01 AI058150NIAID NIH HHS T32 AI074491
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Indexed as

AnimalsAutoantibodiesB-LymphocytesHumansImmune ToleranceLupus Erythematosus, SystemicAutoantibodiesAutoimmunityB cellsLupus

Identifiers

PMID24332482
PMCPMC4053496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.