Evidence map›Paper›PMID 24332389›Full record

ReviewThe Lancet. Infectious diseases2014

Diagnostic point-of-care tests in resource-limited settings.

Paul K Drain, Emily P Hyle, Farzad Noubary, Kenneth A Freedberg, Douglas Wilson, William R Bishai, William Rodriguez, Ingrid V Bassett

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 315 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
315citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02692274 completednot on this mapstarted 2015, after this paper: background citation

Evaluating the Accessibility and Utility of HIV-related Point of Care Diagnostic for Maternal Health in Rural South Africa

TypeobservationalSponsorUniversity of KwaZuluRan2015 to 2016Enrolled309ConditionsHIV
NCT02881398 phase2 / phase3completednot on this map

A Randomized Trial of Pocket-Echocardiography Integrated Mobile Health Device Assessments in Modern Structural Heart Disease Clinics

TypeinterventionalSponsorSri Sathya Sai Institute of Higher Medical SciencesRan2014 to 2016Enrolled253ConditionsRheumatic Heart Disease, Heart DiseasesArmsmHealth, Standard-Care
NCT04500873 completednot on this mapstarted 2018, after this paper: background citation

Diagnostic Performance of a Recombinant Polymerase Amplification Test - Lateral Flow (RPA-LF) for Cutaneous Leishmaniasis in an Endemic Setting of Colombia

TypeobservationalSponsorCentro Internacional de Entrenamiento e Investigaciones MédicasRan2018 to 2019Enrolled128ConditionsCutaneous Leishmaniasis (Diagnosis)
3 · Its place in the literature

Who cites it

315 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  13. Article
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  18. A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  19. Review
  20. Article

255 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Paul K DrainMedical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA. Electronic address: pdrain@partners.org.
Emily P HyleMedical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Farzad NoubaryMedical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA; The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA; Tufts Clinical and Translational Science Institute, Tufts University, Boston, USA.
Kenneth A FreedbergMedical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Douglas WilsonEdendale Hospital, Pietermaritzburg, South Africa.
William R BishaiJohns Hopkins University, Baltimore, USA; KwaZulu-Natal Research Institute for Tuberculosis and HIV, Durban, South Africa.
William RodriguezDaktari Diagnostics, Boston, MA, USA.
Ingrid V BassettMedical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Linkage & Retention: A Randomized Trial to Optimize HIV/TB Care in South AfricaR01MH090326 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BASSETT, INGRID VALERIE · 2010 to 2014
$2.9M
PK/PD Evaluation Resistance Development in Caseating GranulomaR01AI079590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2008 to 2011
$2.5M
Biomarkers and Signaling in TuberculosisR01AI097138 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BISHAI, WILLIAM RAMSES · 2011 to 2014
$2.4M
Clinic-based Screening to Prevent HIV-associated Cryptococcal MortalityK23AI108293 · NIAID · UNIVERSITY OF WASHINGTON · PI DRAIN, PAUL K · 2014 to 2018
$928k
Optimal Strategies for Management of HIV DiseaseK24AI062476 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI FREEDBERG, KENNETH ALAN · 2004 to 2008
$512k
FIC NIH HHS R24 TW007988Howard Hughes Medical InstituteNIAID NIH HHS K23 AI108293NIAID NIH HHS K24 AI062476NIAID NIH HHS R01 AI062476NIAID NIH HHS R01 AI079590NIAID NIH HHS R01 AI097138NIAID NIH HHS T32 AI007433NIMH NIH HHS R01 MH090326
6 · The paper itself

Abstract

The aim of diagnostic point-of-care testing is to minimise the time to obtain a test result, thereby allowing clinicians and patients to make a quick clinical decision. Because point-of-care tests are used in resource-limited settings, the benefits need to outweigh the costs. To optimise point-of-care testing in resource-limited settings, diagnostic tests need rigorous assessments focused on relevant clinical outcomes and operational costs, which differ from assessments of conventional diagnostic tests. We reviewed published studies on point-of-care testing in resource-limited settings, and found no clearly defined metric for the clinical usefulness of point-of-care testing. Therefore, we propose a framework for the assessment of point-of-care tests, and suggest and define the term test efficacy to describe the ability of a diagnostic test to support a clinical decision within its operational context. We also propose revised criteria for an ideal diagnostic point-of-care test in resource-limited settings. Through systematic assessments, comparisons between centralised testing and novel point-of-care technologies can be more formalised, and health officials can better establish which point-of-care technologies represent valuable additions to their clinical programmes.

Indexed as

Diagnostic Tests, RoutineHealth ResourcesHumansPoint-of-Care Systems

Identifiers

PMID24332389
PMCPMC4016042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.