ArticleCancer cell2013
Targeting oxidative stress in embryonal rhabdomyosarcoma.
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In one paragraph
Article in Cancer cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed, 1 pooled it
17.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
204 citing papers in PubMed, 1 synthesis or guideline pooled it, 302 citations in OpenAlex.
- Cancer in Costello syndrome: a systematic review and meta-analysis.British journal of cancer · 2023Pooled it
- Intensive Multiagent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide and Vincristine/Doxorubicin/Cyclophosphamide, Irinotecan, and Radiation, in Patients With High-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Trial
- Molecular Pathogenesis, Tumor Microenvironment and Health Disparities in Select Pediatric Solid Tumors: An Integrative Narrative Review.Diseases (Basel, Switzerland) · 2026Review
- Catalase Defines Radiotherapy Resistance and a Therapeutic Vulnerability in Rhabdomyosarcoma.International journal of molecular sciences · 2026Article
- Paediatric Therapeutic Development Workshop on rhabdomyosarcoma.British journal of cancer · 2026Review
- Maternal residential proximity to oil and gas development in California and the risk of childhood cancer.International journal of hygiene and environmental health · 2026Article
- Dual inhibition of KDM4B and KDM5A disassembles the PAX3-FOXO1 transcriptional program in fusion-positive rhabdomyosarcoma.Biology direct · 2026Article
- Nanotechnology-mediated strategies for skeletal muscle repair and regeneration: targeted intervention, functional remodeling, and translational challenges.Journal of nanobiotechnology · 2026Review
- The landscape of structural variation in pediatric cancer.Cancer cell · 2026Article
- Review
- Choosing the right animal model for sarcoma research.Cellular and molecular life sciences : CMLS · 2026Review
- From bench to bedside: combining HDAC inhibitors with standard therapies in rhabdomyosarcoma treatment.Frontiers in cell and developmental biology · 2026Review
- The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma.Nature communications · 2025Article
- Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence.Cell reports · 2025Article
- Review
- Targeting developmental vulnerabilities in childhood sarcomas.Cancer metastasis reviews · 2025Review
- Article
- Lysine p-nitroanilide impairs cellular energetics and potentiates statin-induced cytotoxicity in RD rhabdomyosarcoma cells.PloS one · 2025Article
- Disrupting resistance: novel therapeutic approaches to combat multidrug resistance in fusion-negative rhabdomyosarcoma.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders.Stem cell research & therapy · 2024Review
144 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
47 authors at 5 institutions in 1 country.
Xiang ChenDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Elizabeth StewartDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Anang A ShelatDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chunxu QuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Armita BahramiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mark HatleyDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gang WuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cori BradleyDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Justina McEvoyDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Alberto PappoDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sheri SpuntDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Marcus B ValentineCytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Virginia ValentineCytogenetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Fred KrafcikDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Walter H LangDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Monika WierdlDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lyudmila TsurkanDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Viktor TollemanDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sara M FedericoDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chris MortonDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Charles LuThe Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA.
Li DingThe Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael RuschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Panduka NagahawatteDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jianmin WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Matthew ParkerDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lei WeiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Erin HedlundDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
David FinkelsteinDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael EdmonsonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sheila ShurtleffDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kristy BoggsDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Heather MulderDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Donald YergeauDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Steve SkapekDivision of Pediatric Hematology-Oncology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Douglas S HawkinsDivision of Hematology-Oncology, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98105, USA.
Nilsa RamirezNationwide Children's Hospital, Columbus, OH 43205, USA.
Philip M PotterDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John A SandovalDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Andrew M DavidoffDepartment of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Elaine R MardisThe Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA.
Richard K WilsonThe Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael A DyerDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: michael.dyer@stjude.org.
St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
St. Jude Children's Research Hospital · USWashington University in St. Louis · USNationwide Children's Hospital · USSeattle Children's Hospital · USSouthwestern Medical Center · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MPROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3MProliferation Control in the Retina: The Rb FamilyR01EY014867 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2003 to 2012
$4.5MProliferation and Differentiation of Retinal Stem CellsR01EY018599 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2008 to 2011
$2.5MEpigenetic Reprogramming of Retinal NeuronsR01EY023619 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2013 to 2017
$2.2MMolecular Targeted Therapy for RetinoblastomaR01CA168875 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2012 to 2016
$1.8MDissection of microRNA-21s role in non-small cell lung cancerK08CA151649 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HATLEY, MARK EDWARD · 2011 to 2015
$842kHoward Hughes Medical InstituteNCI NIH HHS CA168875NCI NIH HHS CA21765NCI NIH HHS K08 CA151649NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA168875NCI NIH HHS R25 CA023944NEI NIH HHS EY014867NEI NIH HHS EY018599NEI NIH HHS R01 EY014867NEI NIH HHS R01 EY018599NEI NIH HHS R01 EY023619
Abstract
Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In contrast, alveolar rhabdomyosarcomas (ARMS) have fewer genetic lesions overall and no known recurrently mutated cancer consensus genes. To identify therapeutics for ERMS, we developed and characterized orthotopic xenografts of tumors that were sequenced in our study. High-throughput screening of primary cultures derived from those xenografts identified oxidative stress as a pathway of therapeutic relevance for ERMS.
Indexed as
Oxidative StressAnimalsClonal EvolutionGene DosageHomeostasisHumansLoss of HeterozygosityMiceMutationRhabdomyosarcoma, Embryonal
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.