Evidence map›Paper›PMID 24332036›Full record

ArticleCancer cell2013

RAS and ROS in rhabdomyosarcoma.

Minsi Zhang, Corinne M Linardic, David G Kirsch

Open access · bronzeAbstract readComment
In one paragraph

Article in Cancer cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Ferroptosis and its role in skeletal muscle diseases.Frontiers in molecular biosciences · 2022
    Review
  8. Review
  9. Metabolic landscapes in sarcomas.Journal of hematology & oncology · 2021
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma.International journal of molecular sciences · 2017
    Review
  15. Uncovering metabolism in rhabdomyosarcoma.Cell cycle (Georgetown, Tex.) · 2016
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Minsi ZhangDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Program in Molecular Cancer Biology, Duke University, Durham, NC 27710, USA.
Corinne M LinardicDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Division of Hematology-Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
David G KirschDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: david.kirsch@duke.edu.
Duke Medical Center · USDuke University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Molecular Modeling of Pediatric Skeletal Muscle TumorsR01CA122706 · NCI · DUKE UNIVERSITY · PI LINARDIC, CORINNE MARY · 2009 to 2013
$1.4M
Independent Scientist Award for Radiation ResearchK02AI093866 · NIAID · DUKE UNIVERSITY · PI KIRSCH, DAVID GUY · 2011 to 2015
$501k
Dissecting the roles of HIF-1a and HIF-2a in tumor response to radiation therapyF30CA180680 · NCI · DUKE UNIVERSITY · PI ZHANG, MINSI · 2013 to 2014
$84k
NCI NIH HHS F30 CA180680NCI NIH HHS R01 CA122706NIAID NIH HHS K02 AI093866NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

The 5-year survival for localized rhabdomyosarcoma is over 70%, but only 30% for patients presenting with metastatic disease. In this issue of Cancer Cell, Chen and colleagues performed whole-genome and RNA sequencing on human rhabdomyosarcoma and identified RAS mutations and oxidative stress as potential therapeutic targets for high-risk embryonal rhabdomyosarcoma.

Indexed as

Oxidative StressAnimalsHumansRhabdomyosarcoma, Embryonal

Identifiers

PMID24332036
PMCPMC3985483
OpenAlexW2089961453

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.