ArticleEuropean journal of radiology2014
Clinical protocols for ³¹P MRS of the brain and their use in evaluating optic pathway gliomas in children.
Article in European journal of radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Pooled it
- A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS andFrontiers in human neuroscience · 2024Article
- Lipid Alterations in Glioma: A Systematic Review.Metabolites · 2022Review
- Interleaved and simultaneous multi-nuclear magnetic resonance in vivo. Review of principles, applications and potential.NMR in biomedicine · 2022Review
- Review
- Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation.Current oncology (Toronto, Ont.) · 2021Article
- 3DNMR in biomedicine · 2021Article
- Cerebral phosphoester signals measured by 31P magnetic resonance spectroscopy at 3 and 7 Tesla.PloS one · 2021Article
- Magnetic Resonance pH Imaging in Stroke - Combining the Old With the New.Frontiers in physiology · 2021Article
- Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.NMR in biomedicine · 2019Review
- Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours.Scientific reports · 2018Article
- Phosphorus magnetic resonance spectroscopic imaging using flyback echo planar readout trajectories.Magma (New York, N.Y.) · 2018Article
- Article
- Multimodal Imaging of Neurometabolic Pathology due to Traumatic Brain Injury.Trends in neurosciences · 2017Review
- PH Measurements of the Brain Using Phosphorus Magnetic Resonance Spectroscopy ((31)PMRS) in Healthy Men - Comparison of Two Analysis Methods.Polish journal of radiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionIn vivo (31)P Magnetic Resonance Spectroscopy (MRS) measures phosphorus-containing metabolites that play an essential role in many disease processes. An advantage over (1)H MRS is that total choline can be separated into phosphocholine and glycerophosphocholine which have opposite associations with tumour grade. We demonstrate (31)P MRS can provide robust metabolic information on an acceptable timescale to yield information of clinical importance.
methodsAll MRI examinations were carried out on a 3T whole body scanner with all (31)P MRS scans conducted using a dual-tuned (1)H/(31)P head coil. Once optimised on phantoms, the protocol was tested in six healthy volunteers (four male and two female, mean age: 25±2.7). (31)P MRS was then implemented on three children with optic pathway gliomas.
results(31)P MRS on volunteers showed that a number of metabolite ratios varied significantly (p<0.05 ANOVA) across different structures of the brain, whereas PC/GPC did not. Standard imaging showed the optic pathway gliomas were enhancing on T1-weighted imaging after contrast injection and have high tCho on (1)H MRS, both of which are associated with high grade lesions. (31)P MRS showed the phosphocholine/glycerophosphocholine ratio to be low (<0.6) which suggests low grade tumours in keeping with their clinical behaviour and the histology of most biopsied optic pathway gliomas.
conclusion(31)P MRS can be implemented in the brain as part of a clinical protocol to provide robust measurement of important metabolites, in particular providing a greater understanding of cases where tCho is raised on (1)H MRS.
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