ArticleBiomaterials2014
Impact of macrophage deficiency and depletion on continuous glucose monitoring in vivo.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Injury to tissue caused by device penetration of the skin triggers formation of extracellular traps.Communications biology · 2025Article
- Impact of Bindarit, a CCL2 Chemokine Synthesis Inhibitor, on Macrophage-Based Biofouling and Continuous Glucose MonitoringBiosensors & bioelectronics: X · 2024Article
- Advanced strategies to thwart foreign body response to implantable devices.Bioengineering & translational medicine · 2022Review
- Influence of diabetes on the foreign body response to nitric oxide-releasing implants.Biomaterials · 2018Article
- Crosslinked basement membrane-based coatings enhance glucose sensor function and continuous glucose monitoring in vivo.Journal of biomedical materials research. Part A · 2018Article
- Impact of CCL2 and CCR2 chemokine/receptor deficiencies on macrophage recruitment and continuous glucose monitoring in vivo.Biosensors & bioelectronics · 2016Article
- Basement Membrane-Based Glucose Sensor Coatings Enhance Continuous Glucose Monitoring in Vivo.Journal of diabetes science and technology · 2015Article
- Modeling the Physiological Factors Affecting Glucose Sensor Function in Vivo.Journal of diabetes science and technology · 2015Article
- Preclinical Performance Evaluation of Percutaneous Glucose Biosensors: Experimental Considerations and Recommendations.Journal of diabetes science and technology · 2015Article
- Macrophage embedded fibrin gels: an in vitro platform for assessing inflammation effects on implantable glucose sensors.Biomaterials · 2014Article
- Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors.Acta biomaterialia · 2014Article
- Cell based metabolic barriers to glucose diffusion: macrophages and continuous glucose monitoring.Biomaterials · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Although it is assumed that macrophages (MQ) have a major negative impact on continuous glucose monitoring (CGM), surprisingly there is no data in the literature to directly support or refute the role of MQ or related foreign body giant cells in the bio-fouling of glucose sensors in vivo. As such, we developed the hypothesis that MQ are key in controlling glucose sensor performance and CGM in vivo and MQ deficiencies or depletion would enhance CGM. To test this hypothesis we determined the presence/distribution of MQ at the sensor tissue interface over a 28-day time period using F4/80 antibody and immunohistochemical analysis. We also evaluated the impact of spontaneous MQ deficiency (op/op mice) and induced-transgenic MQ depletions (Diphtheria Toxin Receptor (DTR) mice) on sensor function and CGM utilizing our murine CGM system. The results of these studies demonstrated: 1) a time dependent increase in MQ accumulation (F4/80 positive cells) at the sensor tissue interface; and 2) MQ deficient mice and MQ depleted C57BL/6 mice demonstrated improved sensor performance (MARD) when compared to normal mice (C57BL/6). These studies directly demonstrate the importance of MQ in sensor function and CGM in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.