Evidence map›Paper›PMID 24331461›Full record

ArticleCell host & microbe2013

Nasal microenvironments and interspecific interactions influence nasal microbiota complexity and S. aureus carriage.

Miling Yan, Sünje J Pamp, Julia Fukuyama, Peter H Hwang, Do-Yeon Cho, Susan Holmes, David A Relman

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05009758 (Moving Towards PREcision Medicine In United Airways Disease), which is not on this map. Cited by 214 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05009758 narecruitingnot on this mapstarted 2021, after this paper: background citation

Moving Towards PREcision Medicine In United Airways Disease: Unraveling inflaMmatory Patterns in Asthmatic Patients With or Without Nasal Polyps (PREMIUM) - a Descriptive Pilot Study

TypeinterventionalSponsorMedical University of ViennaRan2021 to 2026Enrolled30ConditionsAsthma, Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis), Nasal PolypsArmsBlood sampling, Nasosorption, Oral sampling, Bronchoscopy, Nasal biopsy
3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Vitamin D supplementation to persistent carriers of MRSA-a randomized and placebo-controlled clinical trial.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Trial
  6. Trial
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  8. Trial
  9. Article
  10. Article
  11. Article
  12. Observational
  13. D-alanine aminotransferase (Dat) promotesbioRxiv : the preprint server for biology · 2026
    Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miling YanDepartment of Microbiology & Immunology, Stanford University, Stanford, CA 94305, USA.
Sünje J PampDepartment of Microbiology & Immunology, Stanford University, Stanford, CA 94305, USA.
Julia FukuyamaDepartment of Statistics, Stanford University, Stanford, CA 94305, USA.
Peter H HwangDepartment of Otolaryngology, Stanford University, Stanford, CA 94305, USA.
Do-Yeon ChoDepartment of Otolaryngology, Stanford University, Stanford, CA 94305, USA.
Susan HolmesDepartment of Statistics, Stanford University, Stanford, CA 94305, USA.
David A RelmanDepartment of Microbiology & Immunology, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Stanford University, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address: relman@stanford.edu.

Funding

NIH Director's Pioneer AwardDP1OD000964 · OD · STANFORD UNIVERSITY · PI RELMAN, DAVID A. · 2006 to 2010
$3.4M
NIH HHS DP1 OD000964NIH HHS DP1OD000964
6 · The paper itself

Abstract

The indigenous microbiota of the nasal cavity plays important roles in human health and disease. Patterns of spatial variation in microbiota composition may help explain Staphylococcus aureus colonization and reveal interspecies and species-host interactions. To assess the biogeography of the nasal microbiota, we sampled healthy subjects, representing both S. aureus carriers and noncarriers at three nasal sites (anterior naris, middle meatus, and sphenoethmoidal recess). Phylogenetic compositional and sparse linear discriminant analyses revealed communities that differed according to site epithelium type and S. aureus culture-based carriage status. Corynebacterium accolens and C. pseudodiphtheriticum were identified as the most important microbial community determinants of S. aureus carriage, and competitive interactions were only evident at sites with ciliated pseudostratified columnar epithelium. In vitro cocultivation experiments provided supporting evidence of interactions among these species. These results highlight spatial variation in nasal microbial communities and differences in community composition between S. aureus carriers and noncarriers.

Indexed as

AntibiosisBiotaCarrier StateCorynebacteriumHumansNasal MucosaStaphylococcal InfectionsStaphylococcus aureus

Identifiers

PMID24331461
PMCPMC3902146

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.