Evidence map›Paper›PMID 24331112›Full record

ReviewVaccine2013

Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group.

Catherine Satzke, Paul Turner, Anni Virolainen-Julkunen, Peter V Adrian, Martin Antonio, Kim M Hare, Ana Maria Henao-Restrepo, Amanda J Leach, Keith P Klugman, Barbara D Porter and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Vaccine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 289 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
289citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

289 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Differences in Pneumococcal andFrontiers in immunology · 2021
    Trial
  11. Diagnosis of pneumococcal pneumonia using quantitative PCR targeting lytA and piaB in adult patients with community-acquired pneumonia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Digital PCR linkage analysis resolvesMicrobiology spectrum · 2026
    Article
  17. Article
  18. Article
  19. The Lancet regional health. Western Pacific · 2026
    Article
  20. Article

229 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Catherine SatzkePneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Centre for International Child Health, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC, Australia. Electronic address: catherine.satzke@mcri.edu.au.
Paul TurnerMicrobiology Department, Angkor Hospital for Children, Siem Reap, Kingdom of Cambodia; Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom.
Anni Virolainen-JulkunenDepartment of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland.
Peter V AdrianMRC/Wits Respiratory and Meningeal Pathogens Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Martin AntonioMedical Research Council Unit, Banjul, The Gambia.
Kim M HareChild Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Ana Maria Henao-RestrepoInitiative for Vaccine Research, World Health Organization, Geneva, Switzerland.
Amanda J LeachChild Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Keith P KlugmanRollins School of Public Health, Emory University, Atlanta, GA, USA; Respiratory and Meningeal Pathogens Research Unit, University of Witwatersrand, Johannesburg, South Africa.
Barbara D PorterPneumococcal Research, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.
Raquel Sá-LeãoLaboratory of Molecular Microbiology of Human Pathogens, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal.
J Anthony ScottKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; London School of Hygiene & Tropical Medicine, London, UK.
Hanna NohynekVaccine Programme Unit, National Institute for Health and Welfare, Helsinki, Finland.
Katherine L O'BrienDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
WHO Pneumococcal Carriage Working Group

Funding

Wellcome Trust 089275Wellcome Trust 092654Wellcome Trust 098532Wellcome Trust 100714
6 · The paper itself

Abstract

In 2003 the World Health Organization (WHO) convened a working group and published a set of standard methods for studies measuring nasopharyngeal carriage of Streptococcus pneumoniae (the pneumococcus). The working group recently reconvened under the auspices of the WHO and updated the consensus standard methods. These methods describe the collection, transport and storage of nasopharyngeal samples, as well as provide recommendations for the identification and serotyping of pneumococci using culture and non-culture based approaches. We outline the consensus position of the working group, the evidence supporting this position, areas worthy of future research, and the epidemiological role of carriage studies. Adherence to these methods will reduce variability in the conduct of pneumococcal carriage studies undertaken in the context of pneumococcal vaccine trials, implementation studies, and epidemiology studies more generally so variability in methodology does not confound the interpretation of study findings.

Indexed as

Bacteriological TechniquesCarrier StateHumansNasopharynxPneumococcal InfectionsSensitivity and SpecificitySerotypingSpecimen HandlingStreptococcus pneumoniaeCarriageColonizationNasopharynxPneumococcus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.