ArticleParasites & vectors2013
Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key malaria vector in Latin America.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Knockdown resistance (kdr) and organochlorine insecticide resistance in malaria vectors: a systematic review.Malaria journal · 2025Pooled it
- Whole-Genome Resequencing of the VGSC Reveals the Evolutionary Mechanism of Pesticide Resistance inInternational journal of molecular sciences · 2026Article
- Article
- Insecticide susceptibility status of Anopheles albimanus populations in historical malaria foci in Quintana Roo, Mexico.Malaria journal · 2024Article
- Phenotypic resistance not associated with knockdown mutations (kdr) in Anopheles albimanus exposed to deltamethrin in southern coastal Ecuador.Malaria journal · 2024Article
- Article
- Resistance to Pyrethroids in the Malaria VectorInternational journal of environmental research and public health · 2023Article
- Molecular diversity of genes related to biological rhythms (period and timeless) and insecticide resistance (Na V and ace-1) in Anopheles darlingi.Memorias do Instituto Oswaldo Cruz · 2023Article
- Pyrethroid resistance in the New World malaria vector Anopheles albimanus is mediated by cytochrome P450 CYP6P5.Pesticide biochemistry and physiology · 2022Article
- Identification and phylogenetic analysis of voltage-gated sodium channel haplotypes in the malaria vector Anopheles sinensis using a high-throughput amplicon sequencing approach.Parasites & vectors · 2021Article
- Absence of knockdown mutations in pyrethroid and DDT resistant populations of the main malaria vectors in Colombia.Malaria journal · 2019Article
- Pyrethroid exposure alters internal and cuticle surface bacterial communities in Anopheles albimanus.The ISME journal · 2019Article
- Development of molecular assays to detect target-site mechanisms associated with insecticide resistance in malaria vectors from Latin America.Malaria journal · 2019Article
- Article
- Biochemical Basis of Cyfluthrin and DDT Resistance inJournal of arthropod-borne diseases · 2018Article
- Current Susceptibility Status ofJournal of arthropod-borne diseases · 2016Article
- Review
- Diversity and frequency of kdr mutations within Anopheles sinensis populations from Guangxi, China.Malaria journal · 2016Article
- Prospects for malaria elimination in Mesoamerica and Hispaniola.PLoS neglected tropical diseases · 2015Review
- Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids - a review.Parasites & vectors · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnopheles albimanus is a key malaria vector in the northern neotropics. Current vector control measures in the region are based on mass distributions of long-lasting insecticidal nets (LLINs) and focal indoor residual spraying (IRS) with pyrethroids. Resistance to pyrethroid insecticides can be mediated by increased esterase and/or multi-function oxidase activity and/or mutations in the voltage-gated sodium channel gene. The aim of this work was to characterize the homologous kdr region of the voltage-gated sodium channel gene in An. albimanus and to conduct a preliminary retrospective analysis of field samples collected in the 1990's, coinciding with a time of intense pyrethroid application related to agricultural and public health insect control in the region.
methodsDegenerate primers were designed to amplify the homologous kdr region in a pyrethroid-susceptible laboratory strain (Sanarate) of An. albimanus. Subsequently, a more specific primer pair was used to amplify and sequence the region that contains the 1014 codon associated with pyrethroid resistance in other Anopheles spp. (L1014F, L1014S or L1014C).
resultsDirect sequencing of the PCR products confirmed the presence of the susceptible kdr allele in the Sanarate strain (L1014) and the presence of homozygous-resistant kdr alleles in field-collected individuals from Mexico (L1014F), Nicaragua (L1014C) and Costa Rica (L1014C).
conclusionsFor the first time, the kdr region in An. albimanus is described. Furthermore, molecular evidence suggests the presence of kdr-type resistance in field-collected An. albimanus in Mesoamerica in the 1990s. Further research is needed to conclusively determine an association between the genotypes and resistant phenotypes, and to what extent they may compromise current vector control efforts.
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