ArticleJournal of translational medicine2013
Analysis of organ-enriched microRNAs in plasma as an approach to development of Universal Screening Test: feasibility study.
Article in Journal of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Predictive power of circulating miRNAs in detecting colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- The expression and clinical significance of microRNAs in colorectal cancer detecting.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Pooled it
- Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort.PloS one · 2017Trial
- Development of microRNA-Based Glioblastoma Biomarkers Using Blood Plasma Specimens.Diagnostics (Basel, Switzerland) · 2026Article
- Serum microRNAs associated with concussion in football players.Frontiers in neurology · 2023Article
- Nucleic acid biomarkers to assess graft injury after liver transplantation.JHEP reports : innovation in hepatology · 2022Review
- MicroRNAs as Candidate Biomarkers for Alzheimer's Disease.Non-coding RNA · 2021Review
- Predicting Postoperative Liver Dysfunction Based on Blood-Derived MicroRNA Signatures.Hepatology (Baltimore, Md.) · 2019Article
- Age- and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal aging.Aging · 2018Article
- Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.Cancer medicine · 2018Article
- A miRNA Signature for Cognitive Deficits and Alcohol Use Disorder in Persons Living with HIV/AIDS.Frontiers in molecular neuroscience · 2017Article
- miR-203 as a novel biomarker for the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis.OncoTargets and therapy · 2017Article
- Defining Plasma MicroRNAs Associated With Cognitive Impairment In HIV-Infected Patients.Journal of cellular physiology · 2016Article
- Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells.PloS one · 2015Article
- Protein and microRNA biomarkers from lavage, urine, and serum in military personnel evaluated for dyspnea.BMC medical genomics · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly disease detection with a minimally invasive screening test will significantly increase effectiveness and decrease the cost of treatment. Here we propose a framework of a novel approach - Universal Screening Test (UST) for the detection of pathological processes in a particular organ system, organ, or tissue by RT-qPCR analysis of circulating cell-free miRNAs in plasma. As the first step towards assessing the feasibility of this concept, the present study was designed to analyze whether the same microRNAs (miRNAs) can detect various diseases of a particular organ system.
methodsRNA was extracted from plasma using Trizol treatment and silica binding. Levels of miRNAs were measured by single target RT-qPCR. The following innovations have been tested and proven effective: (i) the use of organ system/organ/tissue-enriched miRNAs; (ii) the use of miRNAs associated with broad disease categories, such as cancer and inflammation, in combination with the organ-enriched miRNAs; and (iii) the use of "miRNA pairs" for selecting miRNA combinations with the highest sensitivity and specificity.
resultsHere we report biomarker miRNA pairs effectively differentiating (i) patients with pulmonary system diseases (asthma, pneumonia and non-small cell lung cancer) and gastrointestinal (GI) system diseases (Crohn's disease, stages I/II esophageal, gastric and colon cancers) from controls, each with 95% accuracy; (ii) patients with a pathology of the pulmonary system from patients with a pathology of the GI system with 94% accuracy; and (iii) cancer patients (stages I/II esophageal, gastric, colon cancers, or non-small cell lung cancer) from patients with inflammatory diseases (asthma, pneumonia, or Crohn's disease) with 93%-95% accuracy.
conclusionsThe results obtained in the present study, along with the data reported by us and others previously, are encouraging and lay the ground for further investigation of the described approach for UST development.
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