ArticleCilia2013
Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium.
Article in Cilia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Modulation of Pepsin-Mediated Inflammatory Responses in Vocal Cord Epithelial Cells by Amprenavir.The Laryngoscope · 2026Article
- Review
- Primary cilia and inflammatory response: unveiling new mechanisms in osteoarthritis progression.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte.Cellular and molecular neurobiology · 2024Article
- Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog.Molecular and cellular biology · 2023Article
- HeLa Cervical Cancer Cells Are Maintained by Nephronophthisis 3-Associated Primary Cilium Formation via ROS-Induced ERK and HIF-1α Activation under Serum-Deprived Normoxic Condition.International journal of molecular sciences · 2022Article
- Primary Cilia: A Cellular Regulator of Articular Cartilage Degeneration.Stem cells international · 2022Review
- Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential.Frontiers in cell and developmental biology · 2021Review
- Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction.Osteoarthritis and cartilage · 2021Article
- Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.Journal of cell science · 2020Article
- Primary cilia: Versatile regulator in cartilage development.Cell proliferation · 2020Review
- Oncometabolite induced primary cilia loss in pheochromocytoma.Endocrine-related cancer · 2019Article
- Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- MicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes.Scientific reports · 2017Article
- Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.Journal of neuroinflammation · 2017Article
- Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Primary Cilia and Intraflagellar Transport Proteins in Bone and Cartilage.Journal of dental research · 2016Review
- Endothelial primary cilia inhibit atherosclerosis.EMBO reports · 2016Article
- HIF Stabilization Weakens Primary Cilia.PloS one · 2016Article
- Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.Arthritis research & therapy · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β). We have also shown the primary cilium elongates in response to IL-1β exposure. Both anabolic phenotype and inflammatory pathology are proposed to be dependent on hypoxia-inducible factor 2 alpha (HIF-2α). The present study tests the hypothesis that an association exists between the primary cilium and HIFs in inflammatory signalling.
resultsHere we show, in articular chondrocytes, that IL-1β-induces primary cilia elongation with alterations to cilia trafficking of arl13b. This elongation is associated with a transient increase in HIF-2α expression and accumulation in the primary cilium. Prolyl hydroxylase inhibition results in primary cilia elongation also associated with accumulation of HIF-2α in the ciliary base and axoneme. This recruitment and the associated cilia elongation is not inhibited by blockade of HIFα transcription activity or rescue of basal HIF-2α expression. Hypomorphic mutation to intraflagellar transport protein IFT88 results in limited ciliogenesis. This is associated with increased HIF-2α expression and inhibited response to prolyl hydroxylase inhibition.
conclusionsThese findings suggest that ciliary sequestration of HIF-2α provides negative regulation of HIF-2α expression and potentially activity. This study indicates, for the first time, that the primary cilium regulates HIF signalling during inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.