Evidence map›Paper›PMID 24330698›Full record

ReviewClinical and translational science2013

Pathways of translation: deep brain stimulation.

Michael R Gionfriddo, Alexandra J Greenberg, Abhijeet L Wahegaonkar, Kendall H Lee

Erratum issuedOpen access · bronzeAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael R GionfriddoMayo Graduate School, Mayo Clinic Center for Translational Science Activities, Rochester, Minnesota, USA.
Alexandra J Greenberg
Abhijeet L Wahegaonkar
Kendall H Lee
Mayo Clinic · US

Funding

Mayo Clinic Center for Translational Science ActivitiesTL1RR024152 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$2.5M
WINCS and DBSR01NS070872 · NINDS · MAYO CLINIC ROCHESTER · PI LEE, KENDALL H. · 2011 to 2015
$1.7M
WincsNanotrode development for DBSR01NS075013 · NINDS · MAYO CLINIC ROCHESTER · PI LEE, KENDALL H. · 2011 to 2015
$1.6M
Mechanism of Action of Deep Brain StimulationK08NS052232 · NINDS · MAYO CLINIC ROCHESTER · PI LEE, KENDALL H. · 2008 to 2012
$857k
NCRR NIH HHS TL1 RR0024152NCRR NIH HHS TL1 RR024152NINDS NIH HHS K08 NS052232NINDS NIH HHS K08NS 52232NINDS NIH HHS K08 NS 52252NINDS NIH HHS R01 NS070872NINDS NIH HHS R01 NS075013NINDS NIH HHS R01 NS 70872NINDS NIH HHS R01 NS 74013NINDS NIH HHS R01 NS 75013
6 · The paper itself

Abstract

Electrical stimulation of the brain has a 2000 year history. Deep brain stimulation (DBS), one form of neurostimulation, is a functional neurosurgical approach in which a high-frequency electrical current stimulates targeted brain structures for therapeutic benefit. It is an effective treatment for certain neuropathologic movement disorders and an emerging therapy for psychiatric conditions and epilepsy. Its translational journey did not follow the typical bench-to-bedside path, but rather reversed the process. The shift from ancient and medieval folkloric remedy to accepted medical practice began with independent discoveries about electricity during the 19th century and was fostered by technological advances of the 20th. In this paper, we review that journey and discuss how the quest to expand its applications and improve outcomes is taking DBS from the bedside back to the bench.

Indexed as

Brain WavesDeep Brain StimulationTranslational Research, BiomedicalAnimalsBrainEpilepsyHistory, 19th CenturyHistory, 20th CenturyHistory, 21st CenturyHumansMental Disordersdeep brain stimulationelectrical stimulationneurostimulation

Identifiers

PMID24330698
PMCPMC4057890
OpenAlexW2156434888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.