ArticleBMC plant biology2013
Vernalization treatment induces site-specific DNA hypermethylation at the VERNALIZATION-A1 (VRN-A1) locus in hexaploid winter wheat.
Article in BMC plant biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 58 citations in OpenAlex.
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- Epigenetic control on transcription of vernalization genes and whole-genome gene expression profile induced by vernalization in common wheat.Plant diversity · 2024Article
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- The Change in Whole-Genome Methylation and Transcriptome Profile under Autophagy Defect and Nitrogen Starvation.International journal of molecular sciences · 2023Article
- Duplicate Genes Contribute to Variability in Abiotic Stress Resistance in Allopolyploid Wheat.Plants (Basel, Switzerland) · 2023Review
- Abiotic stress responses in plants.Nature reviews. Genetics · 2022Review
- Plant Responses to Biotic Stress: Old Memories Matter.Plants (Basel, Switzerland) · 2021Review
- In-Depth Sequence Analysis of Bread WheatInternational journal of molecular sciences · 2021Article
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- The epiallelic potential of transposable elements and its evolutionary significance in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Satellite DNA-Mediated Gene Expression Regulation: Physiological and Evolutionary Implication.Progress in molecular and subcellular biology · 2021Article
- Anthocyanin Biosynthesis and DNA Methylation Dynamics in Sweet Orange Fruit [Journal of agricultural and food chemistry · 2020Article
- Characterization of DNA methylation variations during fruit development and ripening ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- Transcriptional regulation of genes bearing intronic heterochromatin in the rice genome.PLoS genetics · 2020Article
- Ectopic expression of LoSVP, a MADS-domain transcription factor from lily, leads to delayed flowering in transgenic Arabidopsis.Plant cell reports · 2020Article
- Small DNA Methylation, Big Player in Plant Abiotic Stress Responses and Memory.Frontiers in plant science · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCertain temperate species require prolonged exposure to low temperature to initiate transition from vegetative growth to flowering, a process known as vernalization. In wheat, winter cultivars require vernalization to initiate flowering, making vernalization requirement a trait of key importance in wheat agronomy. The genetic bases of vernalization response have been largely studied in wheat, leading to the characterization of a regulation pathway that involves the key gene VERNALIZATION1 (VRN1). While previous studies in wheat and barley have revealed the functional role of histone modification in setting VRN1 expression, other mechanisms might also be involved. Here, we were interested in determining whether the cold-induced expression of the wheat VRN-A1 gene is associated with a change in DNA methylation.
resultsWe provide the first DNA methylation analysis of the VRN-A1 gene, and describe the existence of methylation at CG but also at non CG sites. While CG sites show a bell-shape profile typical of gene-body methylation, non CG methylation is restricted to the large (8.5 kb) intron 1, in a region harboring fragments of transposable elements (TEs). Interestingly, cold induces a site-specific hypermethylation at these non CG sites. This increase in DNA methylation is transmitted through mitosis, and is reset to its original level after sexual reproduction.
conclusionsThese results demonstrate that VRN-A1 has a particular DNA methylation pattern, exhibiting rapid shift within the life cycle of a winter wheat plant following exposure to particular environmental conditions. The finding that this shift occurs at non CG sites in a TE-rich region opens interesting questions onto the possible consequences of this type of methylation in gene expression.
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