ReviewCNS neuroscience & therapeutics2014
The role of diffusion tensor imaging in detecting microstructural changes in prodromal Alzheimer's disease.
Review in CNS neuroscience & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Sex- and Age-Dependent Neuroimmune Dysregulation and Early Neurodegenerative Signatures Following SARS-CoV-2 Infection in Golden Syrian Hamsters.Research square · 2026Article
- Mapping Alzheimer's disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures.Scientific reports · 2025Article
- Article
- Glial interactions in the formation and plasticity of the corpus callosum.Frontiers in cellular neuroscience · 2025Review
- Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer's disease progression.Frontiers in aging neuroscience · 2025Article
- PET, SPECT, and MRI imaging for evaluation of Parkinson's disease.American journal of nuclear medicine and molecular imaging · 2024Review
- Predicting conversion from mild cognitive impairment to Alzheimer's disease: a multimodal approach.Brain communications · 2024Article
- Cingulate white matter mediates the effects of fecal Ruminococcus on neuropsychiatric symptoms in patients with amyloid-positive amnestic mild cognitive impairment.BMC geriatrics · 2023Article
- Article
- No laughing white matter: Reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment.Neurobiology of disease · 2023Article
- No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson's Disease.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Multimodal magnetic resonance scans of patients with mild cognitive impairment.Dementia & neuropsychologia · 2023Review
- Correlation between retinal structure and brain multimodal magnetic resonance imaging in patients with Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease.Annals of neurology · 2022Article
- Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Searching for optimal machine learning model to classify mild cognitive impairment (MCI) subtypes using multimodal MRI data.Scientific reports · 2022Article
- Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Herpes simplex virus, early neuroimaging markers and incidence of Alzheimer's disease.Translational psychiatry · 2021Article
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4 authors.
Funding
Abstract
The MRI technique diffusion tensor imaging (DTI) is reviewed along with microstructural changes associated with prodromal Alzheimer's disease (AD) as a potential biomarker for clinical applications. The prodromal stage of AD is characterized by mild cognitive impairment (MCI), representing a transitional state between normal aging and AD. Microstructural abnormalities on DTI are promising in vivo biomarkers of gray and white matter changes associated with the progression of AD pathology. Elevated mean diffusivity and decreased fractional anisotropy are consistently found in prodromal AD, and even in cognitively normal elderly who progress to MCI. However, quality of parameter maps may be affected by artifacts of motion, susceptibility, and eddy current-induced distortions. The DTI maps are typically analyzed by region-of-interest or voxel-based analytic techniques such as tract-based spatial statistics. DTI-based index of diffusivity is complementary to macrostructural gray matter changes in the hippocampus in detecting prodromal AD. Breakdown of structural connectivity measured with DTI may impact cognitive performance during early AD. Furthermore, assessment of hippocampal connections may help in understanding the cerebral organization and remodeling associated with treatment response.
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