ArticleBMC complementary and alternative medicine2013
The antiangiogenic activities of ethanolic crude extracts of four Salvia species.
Article in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- An Ethnopharmacological Survey on Medicinally Important Plants of Genus Salvia.Combinatorial chemistry & high throughput screening · 2025Review
- Natural Compounds ofBiomedicines · 2023Review
- Medicinal plants of Jordan: Scoping review.Heliyon · 2023Article
- In vitro antioxidant, anti-inflammatory, and anticancer activities of mixture Thai medicinal plants.BMC complementary medicine and therapies · 2023Article
- Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics.Frontiers in pharmacology · 2022Review
- Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development.Advanced pharmaceutical bulletin · 2021Review
- Article
- Anti-angiogenic activity of Middle East medicinal plants of the Lamiaceae family.Molecular medicine reports · 2018Article
- Antimigration Activity of an Ethylacetate Fraction of Zanthoxylum acanthopodium DC. Fruits in 4T1 Breast Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Correction to: The antiangiogenic activities of ethanolic crude extracts of four Salvia species.BMC complementary and alternative medicine · 2018Article
- Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo.BMC complementary and alternative medicine · 2014Article
Corrections and comments
- Erratum issuedCorrection to: The antiangiogenic activities of ethanolic crude extracts of four Salvia species.2018 · Somrain, Hamza [corrected to Sumrein, Hamzeh]
Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAngiogenesis is one of cancer hallmarks that are required for both cancer progression and metastasis. In this study we examined the antiangiogenic properties of the ethanolic crude extracts of four Salvia species grown in Jordan.
methodsThe direct antiangiogenic activity was evaluated using various models: ex vivo rat aortic ring assay, in vitro assessment of HUVEC proliferation and migration, and in vivo CAM assay, while we used the changes in the expression of HIF-1α and VEGF in breast cancer cells (MCF 7) as an indicative for the indirect antiangiogenic activity.
resultsAll four crude extracts showed a potential antiangiogenic activity in the rat aortic assay, however two species were found to be cytotoxic against Fibroblast cell line (PLF); the finding that caused the exclusion of these two extracts from further studies. Of the two remaining extracts, S. triloba showed very promising direct and indirect antiangiogenic activities. S. triloba inhibited the HUVEC proliferation with an IC50 of 90 μg/mL and HUVEC migration by 82% at 150 μg/mL. Furthermore, the in vivo CAM assay also illustrated the high impact of S. triloba against the newly formed vessel in the chicken embryonic membrane. Interestingly, the S. triloba inhibited the expression of VEGF at the mRNA and protein and the HIF-1α mRNA in the MCF 7 breast cancer cells under both normoxic and hypoxic conditions.
conclusionsTaken together, all these findings of the direct and indirect angiogenic investigations nominated S. triloba as a highly potent antiangiogenic plant that may have chemotherapeutic and/or chemoprevention potentials.
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