Trial reportBMC infectious diseases2013
Hyponatremia and anti-diuretic hormone in Legionnaires' disease.
Trial report in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Clinical characteristics of Chlamydia psittaci pneumonia diagnosed by next-generation sequencing: An observational study.Medicine · 2026Observational
- The spectrum of legionnaires' disease: a case series illustrating clinical diversity and outcomes.AME case reports · 2026Article
- Diagnosis of acute Q fever using targeted next‑generation sequencing: A case report.Experimental and therapeutic medicine · 2025Article
- Determinant of 30-Day Mortality of Pulmonary Legionellosis: Do Coinfections Matter?Open forum infectious diseases · 2024Article
- Metagenomic next-generation sequencing confirms the diagnosis ofFrontiers in public health · 2023Article
- Inverse relationship between IL-6 and sodium levels in patients with COVID-19 and other respiratory tract infections: data from the COVIVA study.Endocrine connections · 2022Article
- Hyponatremia in horses with septic pneumopathy.Journal of veterinary internal medicine · 2022Article
- The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection.Medicina clinica · 2022Observational
- The impact of the correction of hyponatremia during hospital admission on the prognosis of SARS-CoV-2 infection.Medicina clinica (English ed.) · 2022Article
- A Case of Legionella Pneumonia in an Older Patient Without Typical Exposure to a Susceptive Environment.Cureus · 2022Article
- Article
- Distinct Clinical and Laboratory Patterns ofJournal of fungi (Basel, Switzerland) · 2021Article
- Acute kidney injury and its outcomes in melioidosis.Journal of nephrology · 2021Observational
- Legionnaires' disease arising with hirsutism: case report of an extremely confusing event.BMC infectious diseases · 2021Article
- Prevalence and outcome of dysnatremia in patients with COVID-19 compared to controls.European journal of endocrinology · 2021Observational
- Hyponatremia in Coronavirus Disease-19 Patients: A Retrospective Analysis.Canadian journal of kidney health and disease · 2021Article
- Prevalence and Impact of Hyponatremia in Patients With Coronavirus Disease 2019 in New York City.Critical care medicine · 2020Observational
- Article
- An Observational Study of Sepsis in Takeo Province Cambodia: An in-depth examination of pathogens causing severe infections.PLoS neglected tropical diseases · 2020Observational
- Hyponatremia in Infectious Diseases-A Literature Review.International journal of environmental research and public health · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedical textbooks often list Legionnaires' disease as a differential diagnosis of the syndrome of inappropriate secretion of anti-diuretic hormone (ADH) (SIADH), but evidence supporting this association is largely lacking. We tested the hypothesis whether hyponatremia in patients with Legionnaires' disease would be caused by increased CT-ProVasopressin.
methodsWe measured CT-ProVasopressin and sodium levels in a prospective cohort of 873 pneumonia patients from a previous multicentre study with 27 patients having positive antigen tests for Legionella pneumophila.
resultsPatients with Legionnaires' disease more frequently had low sodium levels (Na < 130 mmol/L) (44.4% vs 8.2%, p < 0.01), but similar mean CT-ProVasopressin levels (pmol/l) (39.4 [±7] vs 51.2 [±2.7], p = 0.43) as compared to patients with pneumonia of other etiologies. In patients with Legionnaires' disease, CT-ProVasopressin levels showed a positive correlation with sodium (r = 0.42, p < 0.05). Independent of pneumonia etiology, CT-ProVasopressin correlated significantly with the pneumonia severity index (r = 0.56, p < 0.05), ICU admission (adjusted odds ratio per decile, 95% CI) (1.6, 1.2 - 2.0), and 30-day-mortality (1.8, 1.3 - 2.4).
conclusionWhile Legionnaires' disease was associated with hyponatremia, no concurrent increase in CT-ProVasopressin levels was found, which argues against elevated ADH levels as the causal pathway to hyponatremia. Rather, Vasopressin precursors were upregulated as response to stress in severe disease, which seems to overrule the osmoregulatory regulation of ADH.
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