Trial reportBMC complementary and alternative medicine2013
Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson's disease: a randomised controlled pilot study.
Trial report in BMC complementary and alternative medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01734876 (Short and Long-term Effects of Tactile Touch on Salivary Cortisol Concentrations in Parkinson's Disease.), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short and Long-term Effects of Tactile Touch on Salivary Cortisol Concentrations in Parkinson's Disease.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- A Systematic Review of Biological Mechanisms and Chronic Pain Outcomes During Stress Reduction Interventions.Biological research for nursing · 2020Pooled it
- Use of Salivary Diurnal Cortisol as an Outcome Measure in Randomised Controlled Trials: a Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Pooled it
- Physiological changes of cortisol and oxytocin following manual therapy: a scoping review.Frontiers in rehabilitation sciences · 2026Review
- Methodological Considerations for Using Hair Cortisol as a Biomarker Following No Measurable Effects of Tactile Massage in Adolescents With ADHD.International journal of pediatrics · 2026Article
- The role of plasma cortisol in dementia, epilepsy, and multiple sclerosis: A Mendelian randomization study.Frontiers in endocrinology · 2023Article
- A New Perspective for Parkinson's Disease: Circadian Rhythm.Neuroscience bulletin · 2017Review
- Covariation between plasma phosphate and daytime cortisol in early Parkinson's disease.Brain and behavior · 2016Article
- Therapies for Parkinson's diseases: alternatives to current pharmacological interventions.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Massage Therapy Treatment and Outcomes for a Patient with Parkinson's Disease: a Case Report.International journal of therapeutic massage & bodywork · 2016Article
- Pain management in patients with Parkinson's disease: challenges and solutions.Journal of multidisciplinary healthcare · 2016Review
- Randomized controlled expressive writing pilot in individuals with Parkinson's disease and their caregivers.BMC psychology · 2015Article
- Mechanisms for alternative treatments in Parkinson's disease: acupuncture, tai chi, and other treatments.Current neurology and neuroscience reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is a chronic neurodegenerative disorder with limited knowledge about the normal function and effects of non-pharmacological therapies on the hypothalamic-pituitary-adrenal (HPA) axis. The aim of the study was to analyse the basal diurnal and total secretion of salivary cortisol in short- and long-term aspects of tactile massage (TM).
methods
designProspective, Controlled and Randomised Multicentre Trial. SETTING AND
interventionsForty-five women and men, aged 50-79 years, were recruited. Twenty-nine of them were blindly randomised to tactile massage (TM) and 16 of them to the control group, rest to music (RTM). Ten interventions were given during 8 weeks followed by a 26 weeks of follow up. Salivary cortisol was collected at 8 am, 1 pm, 8 pm, and 8 am the next day, on five occasions. With the first and eighth interventions, it was collected immediately before and after intervention.
main outcome measuresThe primary aim was to assess and compare cortisol concentrations before and immediately after intervention and also during the follow-up period. The secondary aim was to assess the impact of age, gender, body mass index (BMI), duration and severity of PD, effects of interventional time-point of the day, and levodopa doses on cortisol concentration.
resultsThe median cortisol concentrations for all participants were 16.0, 5.8, 2.8, and 14.0 nmol/L at baseline, later reproduced four times without significant differences. Cortisol concentrations decreased significantly after TM intervention but no change in diurnal salivary cortisol pattern was found. The findings of reduced salivary cortisol concentrations immediately after the interventions are in agreement with previous studies. However, there was no significant difference between the TM and control groups. There were no significant correlations between cortisol concentrations and age, gender, BMI, time-point for intervention, time interval between anti-parkinson pharmacy intake and sampling, levodopa doses, duration, or severity of PD.
conclusionsDiurnal salivary cortisol rhythm was normal. Salivary cortisol concentrations were significantly reduced after the TM intervention and after RTM, but there were no significant differences between the groups and no sustained long-term effect. No associations were seen between salivary cortisol concentration and clinical and/or pharmacological characteristics.
trial registrationClinicalTrial.gov, NCT01734876 and FoU Sweden 108881.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.