Evidence map›Paper›PMID 24330444›Full record

ReviewPaediatric anaesthesia2014

Neonatal pain.

Suellen M Walker

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Paediatric anaesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
11.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03647293 nacompletednot on this mapstarted 2016, after this paper: background citation

Ultrasound Guided Central Line Insertion in Neonates: Pain Score Results From a Prospective Study

TypeinterventionalSponsorSaint George HospitalRan2016 to 2017Enrolled61ConditionsCentral Venous Catheter, Neonates, PainArmsUltrasound Guided Central Catheter Insertion, Peripherally Inserted Central Catheter
NCT05891132 nacompletednot on this mapstarted 2022, after this paper: background citation

Comparison Between the Effects of Lidocaine Prilocaine Cream and Lidocaine Injection on Reduction of Perineal Pain During Episiotomy and Perineum Repair in Vaginal Delivery: Randomized Control Trial

TypeinterventionalSponsorCairo UniversityRan2022 to 2024Enrolled60ConditionsEpisiotomy WoundArms10 ml of lidocaine 2%, lidocaine prilocaine cream 15gm
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Suellen M WalkerPortex Unit: Pain Research, Department of Anaesthesia and Pain Medicine, UCL Institute of Child Health, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
University College London · GB

Funding

Medical Research Council MR/K022636/1
6 · The paper itself

Abstract

Effective management of procedural and postoperative pain in neonates is required to minimize acute physiological and behavioral distress and may also improve acute and long-term outcomes. Painful stimuli activate nociceptive pathways, from the periphery to the cortex, in neonates and behavioral responses form the basis for validated pain assessment tools. However, there is an increasing awareness of the need to not only reduce acute behavioral responses to pain in neonates, but also to protect the developing nervous system from persistent sensitization of pain pathways and potential damaging effects of altered neural activity on central nervous system development. Analgesic requirements are influenced by age-related changes in both pharmacokinetic and pharmacodynamic response, and increasing data are available to guide safe and effective dosing with opioids and paracetamol. Regional analgesic techniques provide effective perioperative analgesia, but higher complication rates in neonates emphasize the importance of monitoring and choice of the most appropriate drug and dose. There have been significant improvements in the understanding and management of neonatal pain, but additional research evidence will further reduce the need to extrapolate data from older age groups. Translation into improved clinical care will continue to depend on an integrated approach to implementation that encompasses assessment and titration against individual response, education and training, and audit and feedback.

Indexed as

AcetaminophenAnalgesics, OpioidAnesthesia, ConductionHumansInfant, NewbornPainPain ManagementPain MeasurementAcetaminophenAnalgesics, OpioidneonateneurodevelopmentNICUopioidspainregional analgesia

Identifiers

PMID24330444
PMCPMC3995005
OpenAlexW4210319906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.