Evidence map›Paper›PMID 24330422›Full record

Trial reportNutrition journal2013

Impact of vitamin A with zinc supplementation on malaria morbidity in Ghana.

Seth Owusu-Agyei, Sam Newton, Emmanuel Mahama, Lawrence Gyabaa Febir, Martha Ali, Kwame Adjei, Kofi Tchum, Latifa Alhassan, Thabisile Moleah, Sherry A Tanumihardjo

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02878265 (The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children), which is not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02878265 phase3completednot on this map

The Effect of Vitamin A With and Without Zinc and Multivitamin Supplementation on Malaria Morbidity in Ghanaian Children

TypeinterventionalSponsorUniversity of GhanaRan2011 to 2012Enrolled547ConditionsMalariaArmsVitamin A, Vitamin A and ZInc, Vitamin A , Zinc and Multivitamin
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  18. Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy.International journal of molecular sciences · 2022
    Review
  19. Review
  20. A literature review on beneficial role of vitamins and trace elements: Evidence from published clinical studies.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Seth Owusu-Agyei
Sam Newton
Emmanuel Mahama
Lawrence Gyabaa Febir
Martha Ali
Kwame Adjei
Kofi Tchum
Latifa Alhassan
Thabisile Moleah
Sherry A Tanumihardjo
Ghana Health Service · GHKintampo Health Research Centre · GHInternational Atomic Energy Agency · ATUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria is a leading cause of morbidity and mortality among young children and is estimated to cause at least 1 million deaths each year especially among pregnant women and young children under the age of five years. Vitamin A supplementation is known to reduce morbidity and mortality in young children. Zinc is required for growth and immunity and we sought to replicate the study by Zeba et al. which showed 30% lower cases of clinical malaria in children on a combination of zinc and a large dose of vitamin A compared with children on vitamin A alone based on the hypothesis that combined vitamin A and zinc reduced symptomatic malaria compared to vitamin A alone.

objectivesThe primary objective was to determine the effect of vitamin A alone vs. vitamin A and zinc supplements on the incidence of clinical malaria and other anthropometric indices. It also sought to assess the effects on the incidence of anaemia, diarrhoea and pneumonia.

methodsThe study was community-based and 200 children between the ages of 6-24 months were randomised to receive either vitamin A (100,000 IU for infants less than 12 months & 200,000 IU for children greater than 12 months and 10 mg daily zinc in the intervention group or vitamin A and zinc placebo for 6 months in the control group.

resultsThe number of children who were diagnosed with uncomplicated malaria in the intervention group was 27% significantly lower compared with the children in the control group (p = 0.03). There were, however, no effects on severe malaria, pneumonia, anaemia and diarrhea.

conclusionsOur study confirms a significant role of vitamin A and zinc in reducing malaria morbidity.

Indexed as

Dietary SupplementsRural HealthAnemiaChild DevelopmentChild, PreschoolDeveloping CountriesDiarrheaFemaleGhanaHumansIncidenceInfantLongitudinal StudiesLost to Follow-UpMalariaMaleVitamin AZinc

Identifiers

PMID24330422
PMCPMC3850154
OpenAlexW2134718973

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.