ArticleMolecular microbiology2014
Beyond catalysis: vitamin B12 as a cofactor in gene regulation.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Phenomenal Diversity of the Photosynthetic Apparatus Evolved in Aerobic Anoxygenic Phototrophs.Microorganisms · 2025Review
- Transcriptomic and proteomic changes associated with cobalamin-dependent propionate production by the rumen bacteriummSystems · 2024Article
- Insights into the Lysine Acetylome of the HaloarchaeonAntioxidants (Basel, Switzerland) · 2023Article
- The Small RNA-Binding Protein CcaF1 Promotes Formation of Photosynthetic Complexes inInternational journal of molecular sciences · 2023Article
- Reprocessing of side-streams towards obtaining valuable bacterial metabolites.Applied microbiology and biotechnology · 2023Review
- Molecular Recognition Patterns between Vitamin B12 and Proteins Explored through STD-NMR and In Silico Studies.Foods (Basel, Switzerland) · 2023Article
- Ribonuclease E strongly impacts bacterial adaptation to different growth conditions.RNA biology · 2023Article
- Regulation of Gene Expression Through Effector-dependent Conformational Switching by Cobalamin Riboswitches.Journal of molecular biology · 2022Review
- Interplay between chromophore binding and domain assembly by the BChemical science · 2021Article
- Microbial and Genetic Resources for Cobalamin (Vitamin B12) Biosynthesis: From Ecosystems to Industrial Biotechnology.International journal of molecular sciences · 2021Review
- Adaptation to Photooxidative Stress: Common and Special Strategies of the AlphaproteobacteriaMicroorganisms · 2020Article
- Binding studies of a putative C. pseudotuberculosis target protein from Vitamin BScientific reports · 2019Article
- Oral vitamin BGut microbes · 2019Article
- A Cobalamin Activity-Based Probe Enables Microbial Cell Growth and Finds New Cobalamin-Protein Interactions across Domains.Applied and environmental microbiology · 2018Article
- Fast removal of Co(ii) from aqueous solution using porous carboxymethyl chitosan beads and its adsorption mechanism.RSC advances · 2018Article
- Elucidation of roles for vitamin BProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Structure and function of a short LOV protein from the marine phototrophic bacterium Dinoroseobacter shibae.BMC microbiology · 2015Article
- Vitamin B12 as a modulator of gut microbial ecology.Cell metabolism · 2014Review
- Gene co-expression network analysis in Rhodobacter capsulatus and application to comparative expression analysis of Rhodobacter sphaeroides.BMC genomics · 2014Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Vitamin B12 is well known as an enzyme cofactor in the catalysis of many important biological reactions, and the role of B12 in regulation of bacterial gene expression as a ligand of riboswitches is well established. Only recently evidence has emerged that B12 can also affect bacterial gene expression by acting as a cofactor of regulatory proteins. In 2011 a role of B12 as a cofactor of the transcriptional repressor of carotenogenesis, CarH, in Myxococcus xanthus was reported. B12 is required for light-dependent DNA binding by CarH, which can therefore be considered to be a new type of photoreceptor. Cheng et al. (2014) report the identification of B12 as a cofactor of the AerR protein in Rhodobacter capsulatus. AerR acts as an antirepressor of the CrtJ protein, which represses photosynthesis genes when binding to its target promoters. As in Myxococcus B12 may have the role of a chromophore in photoreception, but it is suggested that a main function of AerR is the sensing of B12. The co-regulation of the pathways is beneficial because the syntheses of B12 , haem and bacteriochlorophylls share common precursors and the accumulation of the free molecules is toxic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.