ArticleBMC musculoskeletal disorders2013
Risk factors for incident hyperuricemia during mid-adulthood in African American and white men and women enrolled in the ARIC cohort study.
Article in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Socioeconomic differences in hyperuricemia and gout: a systematic review and meta-analysis.Endocrine · 2020Pooled it
- Effects of Lowering Glycemic Index of Dietary Carbohydrate on Plasma Uric Acid Levels: The OmniCarb Randomized Clinical Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2016Trial
- Longitudinal serum uric acid transition patterns and their clinical, genetic, and dietary determinants: prospective prediction of incident hyperuricemia and gout in a Korean population-based cohort.Clinical rheumatology · 2026Article
- Association between secondhand smoke exposure and hyperuricemia among never smokers: A cross-sectional analysis of NHANES data.Tobacco induced diseases · 2026Article
- Urine Metabolomics of Gout Reveals the Dynamic Reprogramming and Non-Invasive Biomarkers of Disease Progression.Metabolites · 2025Article
- The association between smoking and the occurrence of hyperuricemia: A retrospective cohort study.Tobacco induced diseases · 2025Article
- Dissecting the risk factors for hyperuricemia in vegetarians in Taiwan.Journal of the Chinese Medical Association : JCMA · 2024Article
- Impact of IL-17A Inhibitors on Serum Uric Acid Levels in Psoriatic Patients with Hyperuricemia: A Prospective Observational Study.Psoriasis (Auckland, N.Z.) · 2024Article
- Association of oxidative balance score with hyperuricemia and gout: NHANES 2009-2018.Frontiers in endocrinology · 2024Article
- Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study.Nutrients · 2023Observational
- Incidence density of hyperuricemia and association between metabolism-related predisposing risk factors and serum urate in Chinese adults: a cohort study.Frontiers in endocrinology · 2023Article
- Article
- A cross-sectional study on the association between dietary inflammatory index and hyperuricemia based on NHANES 2005-2018.Frontiers in nutrition · 2023Article
- Racial and Sex Disparities in Gout Prevalence Among US Adults.JAMA network open · 2022Article
- Association between circulating cystatin C and hyperuricemia: a cross-sectional study.Clinical rheumatology · 2022Article
- Prevalence and risk factors of hyperuricaemia in non-obese Chinese: a single-centre cross-sectional study.BMJ open · 2022Article
- The relationship between polymorphism of insulin-like growth factor I gene and susceptibility to type 2 diabetes in Uygur population, Xinjiang, China.Genes & genomics · 2022Article
- An Unusual Case of Kidney Injury in a Young Woman with a Connective Tissue Disease.Case reports in nephrology · 2022Article
- The Association Between Spicy Food Intake and Risk of Hyperuricemia Among Chinese Adults.Frontiers in public health · 2022Article
- Relationship between bisphenol A, bisphenol S, and bisphenol F and serum uric acid concentrations among school-aged children.PloS one · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIncreased serum urate levels are associated with poor outcomes including but not limited to gout. It is unclear whether serum urate levels are the sole predictor of incident hyperuricemia or whether demographic and clinical risk factors also predict the development of hyperuricemia. The goal of this study was to identify risk factors for incident hyperuricemia over 9 years in a population-based study, ARIC.
methodsARIC recruited individuals from 4 US communities; 8,342 participants who had urate levels <7.0 mg/dL were included in this analysis. Risk factors (including baseline, 3-year, and change in urate level over 3 years) for 9-year incident hyperuricemia (urate level of >7.0 g/dL) were identified using an AIC-based selection approach in a modified Poisson regression model.
resultsThe 9-year cumulative incidence of hyperuricemia was 4%; men = 5%; women = 3%; African Americans = 6% and whites = 3%. The adjusted model included 9 predictors for incident hyperuricemia over 9 years: male sex (RR = 1.73 95% CI: 1.36-2.21), African-American race (RR = 1.79 95% CI: 1.37-2.33), smoking (RR = 1.27, 95% CI: 0.97-1.67), <HS education (RR = 1.27, 95% CI: 0.99-1.63), hypertension (RR = 1.65, 95% CI: 1.30-2.09), CHD (RR = 1.57, 95% CI: 0.99-2.50), obesity (class I RR = 2.37, 95% CI: 1.65-3.41 and ≥ class II RR = 3.47, 95% CI: 2.33-5.18), eGFR < 60 (RR = 2.85, 95% CI: 1.62-5.01) and triglycerides (Quartile 4 vs. Quartile 1: RR = 2.00, 95% CI: 1.38-2.89). In separate models, urate levels at baseline (RR 1 mg/dL increase = 2.33, 95% CI: 1.94-2.80) and 3 years after baseline (RR for a 1 mg/dL increase = 1.92, 95% CI: 1.78-2.07) were associated with incident hyperuricemia after accounting for demographic and clinical risk factors.
conclusionDemographic and clinical risk factors that are routinely collected as part of regular medical care are jointly associated with the development of hyperuricemia.
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