ArticleJournal of evolutionary biology2014
The effect of population bottlenecks on mutation rate evolution in asexual populations.
Article in Journal of evolutionary biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- SynonymousNAR genomics and bioinformatics · 2024Article
- Selecting for infectivity across metapopulations can increase virulence in the social microbeEvolutionary applications · 2023Article
- Evolutionary Dynamics of Asexual Hypermutators Adapting to a Novel Environment.Genome biology and evolution · 2021Article
- Antitumor Drugs and Their Targets.Molecules (Basel, Switzerland) · 2020Review
- Migration promotes mutator alleles in subdivided populations.Evolution; international journal of organic evolution · 2019Article
- The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology.Frontiers in genetics · 2019Review
- Article
- Sign of selection on mutation rate modifiers depends on population size.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Microalgae for the production of lipid and carotenoids: a review with focus on stress regulation and adaptation.Biotechnology for biofuels · 2018Review
- A Model for Designing Adaptive Laboratory Evolution Experiments.Applied and environmental microbiology · 2017Article
- Known mutator alleles do not markedly increase mutation rate in clinicalProceedings. Biological sciences · 2017Article
- Variability in fitness effects can preclude selection of the fittest.Annual review of ecology, evolution, and systematics · 2017Article
- Benefits of a Recombination-Proficient Escherichia coli System for Adaptive Laboratory Evolution.Applied and environmental microbiology · 2016Article
- Repeatability of adaptation in experimental populations of different sizes.Proceedings. Biological sciences · 2015Article
- Review
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Authors and funding
3 authors.
Funding
Abstract
In the absence of recombination, a mutator allele can spread through a population by hitchhiking with beneficial mutations that appear in its genetic background. Theoretical studies over the past decade have shown that the survival and fixation probability of beneficial mutations can be severely reduced by population size bottlenecks. Here, we use computational modelling and evolution experiments with the yeast S. cerevisiae to examine whether population bottlenecks can affect mutator dynamics in adapting asexual populations. In simulation, we show that population bottlenecks can inhibit mutator hitchhiking with beneficial mutations and are most effective at lower beneficial mutation supply rates. We then subjected experimental populations of yeast propagated at the same effective population size to three different bottleneck regimes and observed that the speed of mutator hitchhiking was significantly slower at smaller bottlenecks, consistent with our theoretical expectations. Our results, thus, suggest that bottlenecks can be an important factor in mutation rate evolution and can in certain circumstances act to stabilize or, at least, delay the progressive elevation of mutation rates in asexual populations. Additionally, our findings provide the first experimental support for the theoretically postulated effect of population bottlenecks on beneficial mutations and demonstrate the usefulness of studying mutator frequency dynamics for understanding the underlying dynamics of fitness-affecting mutations.
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