ReviewMalaria journal2013
The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.
Review in Malaria journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comprehensive review of antimalarial medicinal plants used by Tanzanians.Pharmaceutical biology · 2024Pooled it
- Isolation, purification and characterization of betulinic acid derivative from the root bark ofInternational journal of biochemistry and molecular biology · 2026Article
- Phytochemical profiling and bioactive potential of bael gum using UHPLC-Q-TOF-MS: a novel nutraceutical source.Frontiers in nutrition · 2025Article
- Machine-Learning- and Structure-Based Virtual Screening for Selecting Cinnamic Acid Derivatives asMolecules (Basel, Switzerland) · 2023Article
- Article
- Furoquinoline Alkaloids: Insights into Chemistry, Occurrence, and Biological Properties.International journal of molecular sciences · 2023Review
- Antimicrobial andHeliyon · 2023Article
- Medicinal plants used for treatment of malaria by indigenous communities of Tororo District, Eastern Uganda.Tropical medicine and health · 2023Article
- Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria.BMC complementary medicine and therapies · 2023Article
- Striving towards true equity in global health: A checklist for bilateral research partnerships.PLOS global public health · 2023Review
- Identification and Comparison of Bioactive Components of TwoPlants (Basel, Switzerland) · 2022Article
- Exploring Potential Antimalarial Candidate from Medicinal Plants of Kheaw Hom Remedy.Tropical medicine and infectious disease · 2022Article
- Plants as Sources of Natural and Recombinant Antimalaria Agents.Molecular biotechnology · 2022Review
- Natural products-based: Synthesis and antifungal activity evaluation of novel L-pyroglutamic acid analogues.Frontiers in plant science · 2022Article
- Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite.Current topics in medicinal chemistry · 2022Review
- Antiplasmodial activity and cytotoxicity of plant extracts from the Asteraceae and Rubiaceae families.Heliyon · 2022Article
- African Herbal Medicines: Adverse Effects and Cytotoxic Potentials with Different Therapeutic Applications.International journal of environmental research and public health · 2021Review
- Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Anti-MRSA Constituents fromMolecules (Basel, Switzerland) · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional medicine caters for about 80% of the health care needs of many rural populations around the world, especially in developing countries. In addition, plant-derived compounds have played key roles in drug discovery. Malaria is currently a public health concern in many countries in the world due to factors such as chemotherapy faced by resistance, poor hygienic conditions, poorly managed vector control programmes and no approved vaccines. In this review, an attempt has been made to assess the value of African medicinal plants for drug discovery by discussing the anti-malarial virtue of the derived phytochemicals that have been tested by in vitro and in vivo assays. This survey was focused on pure compounds derived from African flora which have exhibited anti-malarial properties with activities ranging from "very active" to "weakly active". However, only the compounds which showed anti-malarial activities from "very active" to "moderately active" are discussed in this review. The activity of 278 compounds, mainly alkaloids, terpenoids, flavonoids, coumarines, phenolics, polyacetylenes, xanthones, quinones, steroids, and lignans have been discussed. The first part of this review series covers the activity of 171 compounds belonging to the alkaloid and terpenoid classes. Data available in the literature indicated that African flora hold an enormous potential for the development of phytomedicines for malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.