ArticleBMC immunology2013
An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.
Article in BMC immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- IgE based therapeutics are an emerging modality in cancer treatment.Discover oncology · 2025Review
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Humanized FcεRI Expressed on Mouse Eosinophils Mediates IgE-Facilitated Eosinophil Antigen Presentation.Cells · 2025Article
- The rationale for development of ligelizumab in food allergy.The World Allergy Organization journal · 2022Review
- Aeroallergens in Atopic Dermatitis and Chronic Urticaria.Current allergy and asthma reports · 2022Review
- A positive feedback loop reinforces the allergic immune response in human peanut allergy.The Journal of experimental medicine · 2021Article
- Genetically engineered fusion of allergen and viral-like particle induces a more effective allergen-specific immune response than a combination of them.Applied microbiology and biotechnology · 2021Article
- Pre-Existing Humoral Immunity Enhances Epicutaneously-Administered Allergen Capture by Skin DC and Their Migration to Local Lymph Nodes.Frontiers in immunology · 2021Article
- Dendritic Cells: Critical Regulators of Allergic Asthma.International journal of molecular sciences · 2020Review
- Photocrosslinkable Gelatin Hydrogels Modulate the Production of the Major Pro-inflammatory Cytokine, TNF-α, by Human Mononuclear Cells.Frontiers in bioengineering and biotechnology · 2018Article
- dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies.International journal of molecular sciences · 2017Review
- Image based Machine Learning for identification of macrophage subsets.Scientific reports · 2017Article
- The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.Scientific reports · 2017Article
- Dendritic Cell Subsets in Asthma: Impaired Tolerance or Exaggerated Inflammation?Frontiers in immunology · 2017Review
- Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.The Journal of allergy and clinical immunology · 2015Article
- Atopic donor status does not influence the uptake of the major grass pollen allergen, Phl p 5, by dendritic cells.Journal of immunological methods · 2015Article
- The role of FcεRI expressed in dendritic cells and monocytes.Cellular and molecular life sciences : CMLS · 2015Review
- Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation.Molecular pharmaceutics · 2014Article
- New strategies with anti-IgE in allergic diseases.The World Allergy Organization journal · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the uptake of the house dust mite glycoallergen Der p 1 by DCs. In addition to mannose receptor (MR) and DC-SIGN the high and low affinity IgE receptors, namely FcεRI and FcεRII (CD23), respectively, have been shown to be involved in allergen uptake and presentation by DCs.
objectivesThis study aims at understanding the extent to which IgE- and IgG-facilitated Der p 1 uptake by DCs influence T cell polarisation and in particular potential bias in favour of Th2. We have addressed this issue by using two chimaeric monoclonal antibodies produced in our laboratory and directed against a previously defined epitope on Der p 1, namely human IgE 2C7 and IgG1 2C7.
resultsFlow cytometry was used to establish the expression patterns of IgE (FcεRI and FcεRII) and IgG (FcγRI) receptors in relation to MR on DCs. The impact of FcεRI, FcεRII, FcγRI and mannose receptor mediated allergen uptake on Th1/Th2 cell differentiation was investigated using DC/T cell co-culture experiments. Myeloid DCs showed high levels of FcεRI and FcγRI expression, but low levels of CD23 and MR, and this has therefore enabled us to assess the role of IgE and IgG-facilitated allergen presentation in T cell polarisation with minimal interference by CD23 and MR. Our data demonstrate that DCs that have taken up Der p 1 via surface IgE support a Th2 response. However, no such effect was demonstrable via surface IgG.
conclusionsIgE bound to its high affinity receptor plays an important role in Der p 1 uptake and processing by peripheral blood DCs and in Th2 polarisation of T cells.
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