ArticleAddiction (Abingdon, England)2014
Striatum and insula dysfunction during reinforcement learning differentiates abstinent and relapsed methamphetamine-dependent individuals.
Article in Addiction (Abingdon, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response.Drug and alcohol dependence · 2016Trial
- Mesocorticolimbic Dopamine-Reward Tract Alterations and the 'Dark Side' of Methamphetamine Addiction.Addiction biology · 2026Article
- Task-dependent increases and decreases of BOLD signal in theory of mind brain regions during strategic social interaction.Frontiers in neural circuits · 2026Article
- Abnormal regional brain activity associated with relapse in early abstinent methamphetamine-dependent individuals.Scientific reports · 2025Article
- Amygdala Network Dynamics During Drug Cue Processing in Methamphetamine Use Disorder.Basic and clinical neuroscience · 2025Article
- Reinforcement learning processes as forecasters of depression remission.Journal of affective disorders · 2025Article
- Neural correlates of model-based behavior in internet gaming disorder and alcohol use disorder.Journal of behavioral addictions · 2024Article
- Connecting Circuits with Networks in Addiction Neuroscience: A Salience Network Perspective.International journal of molecular sciences · 2023Review
- Temporally dynamic neural correlates of drug cue reactivity, response inhibition, and methamphetamine-related response inhibition in people with methamphetamine use disorder.Scientific reports · 2022Article
- Computational reinforcement learning, reward (and punishment), and dopamine in psychiatric disorders.Frontiers in psychiatry · 2022Review
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Neurocognition in stimulant addiction: reply to Robbins (2021).Psychoradiology · 2021Article
- Glutamatergic input from the insula to the ventral bed nucleus of the stria terminalis controls reward-related behavior.Addiction biology · 2021Article
- Limited versus extended cocaine intravenous self-administration: Behavioral effects and electrophysiological changes in insular cortex.CNS neuroscience & therapeutics · 2021Article
- Differential alterations of insular cortex excitability after adolescent or adult chronic intermittent ethanol administration in male rats.Journal of neuroscience research · 2021Article
- Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder: A Review.JAMA psychiatry · 2020Review
- Dark Times: The Role of Negative Reinforcement in Methamphetamine Addiction.Frontiers in psychiatry · 2020Review
- Disturbances across whole brain networks during reward anticipation in an abstinent addiction population.NeuroImage. Clinical · 2020Article
- Model-Free and Model-Based Influences in Addiction-Related Behaviors.Biological psychiatry · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsIndividuals with methamphetamine dependence (MD) exhibit dysfunction in brain regions involved in goal maintenance and reward processing when compared with healthy individuals. We examined whether these characteristics also reflect relapse vulnerability within a sample of MD patients.
designLongitudinal, with functional magnetic resonance imaging (fMRI) and clinical interview data collected at baseline and relapse status collected at 1-year follow-up interview.
settingKeck Imaging Center, University of California San Diego, USA.
participantsMD patients (n = 60) enrolled into an in-patient drug treatment program at baseline. MD participants remaining abstinent at 1-year follow-up (abstinent MD group; n = 42) were compared with MD participants who relapsed within this period (relapsed MD group; n = 18). MEASUREMENTS: Behavioral and neural responses to a reinforcement learning (paper-scissors-rock) paradigm recorded during an fMRI session at time of treatment.
findingsThe relapsed MD group exhibited greater bilateral inferior frontal gyrus (IFG) and right striatal activation than the abstinent MD group during the learning of reward contingencies (Cohen's d range: 0.60-0.83). In contrast, the relapsed MD group displayed lower bilateral striatum, bilateral insula, left IFG and left anterior cingulate activation than the abstinent MD group (Cohen's d range: 0.90-1.23) in response to winning, tying and losing feedback.
conclusionsMethamphetamine-dependent individuals who achieve abstinence and then relapse show greater inferior frontal gyrus activation during learning, and relatively attenuated striatal, insular and frontal activation in response to feedback, compared with methamphetamine-dependent people who remain abstinent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.