ArticleThe European journal of neuroscience2014
Respiratory cycle entrainment of septal neurons mediates the fast coupling of sniffing rate and hippocampal theta rhythm.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- Sniffing Like a Wine Taster: Multiple Overlapping Sniffs (MOSS) Strategy Enhances Electronic Nose Odor Recognition Capability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Modeling the contribution of theta-gamma coupling to sequential memory, imagination, and dreaming.Frontiers in neural circuits · 2024Article
- Circuit formation and sensory perception in the mouse olfactory system.Frontiers in neural circuits · 2024Review
- The effect of ketamine on delta-range coupling between prefrontal cortex and hippocampus supported by respiratory rhythmic input from the olfactory bulb.Brain research · 2022Article
- Macroscale connections of the mouse lateral preoptic area and anterior lateral hypothalamic area.The Journal of comparative neurology · 2022Article
- Basal Forebrain Impairment: Understanding the Mnemonic Function of the Septal Region Translates in Therapeutic Advances.Frontiers in neural circuits · 2022Review
- Long-Range Respiratory and Theta Oscillation Networks Depend on Spatial Sensory Context.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Human hippocampal connectivity is stronger in olfaction than other sensory systems.Progress in neurobiology · 2021Article
- Changing phase relationship of the stepping rhythm to neuronal oscillatory theta activity in the septo-hippocampal network of mice.Brain structure & function · 2020Article
- A New Unifying Account of the Roles of Neuronal Entrainment.Current biology : CB · 2019Review
- The rhythm of memory: how breathing shapes memory function.Journal of neurophysiology · 2019Review
- Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice.PLoS biology · 2019Article
- Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats.Journal of neurophysiology · 2018Article
- Automated analysis of breathing waveforms using BreathMetrics: a respiratory signal processing toolbox.Chemical senses · 2018Article
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Breathing above the brain stem: volitional control and attentional modulation in humans.Journal of neurophysiology · 2018Article
- Characterization of Peripheral Activity States and Cortical Local Field Potentials of Mice in an Elevated Plus Maze Test.Frontiers in behavioral neuroscience · 2018Article
- Tracking of unfamiliar odors is facilitated by signal amplification through anoctamin 2 chloride channels in mouse olfactory receptor neurons.Physiological reports · 2017Article
- Speed and Oscillations: Medial Septum Integration of Attention and Navigation.Frontiers in systems neuroscience · 2017Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Memory for odour information may result from temporal coupling between the olfactory and hippocampal systems. Respiration defines the frequency of olfactory perception, but how the respiratory rate affects hippocampal oscillations remains poorly understood. The afferent connectivity of the medial septum/diagonal band of Broca complex (MS/DB) proposes this region as a crossroads between respiratory and limbic pathways. Here we investigate if the firing rates of septal neurons integrate respiratory rate signals. We demonstrate that approximately 50% of MS/DB neurons are temporally correlated with sniffing frequency. Moreover, a group of slow-spiking septal neurons are phase-locked to the sniffing cycle. We show that inter-burst intervals of MS/DB theta cells relate to the sniff rate. Intranasal odour infusion evokes sniff phase preference for the activity of fast-spiking MS/DB neurons. Concurrently, the infusion augments the correlation between sniffing and limbic theta oscillations. During periods of sniffing-theta correlation, CA1 place cells fired preferentially during the inhalation phase, suggesting the theta cycle as a coherent time frame for central olfactory processing. Furthermore, injection of the GABAergic agonist muscimol into medial septum induces a parallel decrease of sniffing and theta frequencies. Our findings provide experimental evidence that MS/DB does not merely generate theta rhythm, but actively integrates sensorimotor stimuli that reflect sniffing rate. Such integration may provide temporal oscillatory synchronisation of MS/DB-innervated limbic structures with the sniffing cycle.
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