ArticleMolecular microbiology2014
Vitamin B12 regulates photosystem gene expression via the CrtJ antirepressor AerR in Rhodobacter capsulatus.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 56 citations in OpenAlex.
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- Transcriptomic and proteomic changes associated with cobalamin-dependent propionate production by the rumen bacteriummSystems · 2024Article
- The blue light-dependent LOV-protein LdaP ofFrontiers in microbiology · 2024Article
- A singular PpaA/AerR-like protein inmSystems · 2023Article
- Redox Brake Regulator RedB and FnrL Function as Yin-Yang Regulators of Anaerobic-Aerobic Metabolism in Rhodobacter capsulatus.Microbiology spectrum · 2022Article
- Structural Analyses of CrtJ and Its BMicroorganisms · 2022Article
- Role of the CarH photoreceptor protein environment in the modulation of cobalamin photochemistry.Biophysical journal · 2021Article
- Interplay between chromophore binding and domain assembly by the BChemical science · 2021Article
- Interactions among Redox Regulators and the CtrA Phosphorelay inMicroorganisms · 2020Article
- Adaptation to Photooxidative Stress: Common and Special Strategies of the AlphaproteobacteriaMicroorganisms · 2020Article
- Differing isoforms of the cobalamin binding photoreceptor AerR oppositely regulate photosystem expression.eLife · 2018Article
- Engineering a vitamin BBMC biotechnology · 2018Article
- Transcriptomic analysis of aerobic respiratory and anaerobic photosynthetic states inMicrobial genomics · 2017Article
- A New Facet of Vitamin BAnnual review of biochemistry · 2017Review
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- The Vitamin BmBio · 2017Article
- Microbial production of vitamin BMicrobial cell factories · 2017Review
- Cobalamin's (Vitamin B12) Surprising Function as a Photoreceptor.Trends in biochemical sciences · 2016Article
- Deciphering the Transcriptional Response Mediated by the Redox-Sensing System HbpS-SenS-SenR from Streptomycetes.PloS one · 2016Article
- Analysis of the FnrL regulon in Rhodobacter capsulatus reveals limited regulon overlap with orthologues from Rhodobacter sphaeroides and Escherichia coli.BMC genomics · 2015Article
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5 authors at 1 institution in 1 country.
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Abstract
The tetrapyrroles haem, bacteriochlorophyll and cobalamin (B12 ) exhibit a complex interrelationship regarding their synthesis. In this study, we demonstrate that AerR functions as an antirepressor of the tetrapyrrole regulator CrtJ. We show that purified AerR contains B12 that is bound to a conserved histidine (His145) in AerR. The interaction of AerR to CrtJ was further demonstrated in vitro by pull down experiments using AerR as bait and quantified using microscale thermophoresis. DNase I DNA footprint assays show that AerR containing B12 inhibits CrtJ binding to the bchC promoter. We further show that bchC expression is greatly repressed in a B12 auxotroph of Rhodobacter capsulatus and that B12 regulation of gene expression is mediated by AerR's ability to function as an antirepressor of CrtJ. This study thus provides a mechanism for how the essential tetrapyrrole, cobalamin controls the synthesis of bacteriochlorophyll, an essential component of the photosystem.
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