ArticleTissue engineering. Part A2014
Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- An exploratory in vitro co-culture of enteric neurons and smooth muscle cells demonstrates neuronal contribution to muscle layer formation.Scientific reports · 2026Article
- Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering.Military Medical Research · 2024Review
- Review
- Gut bioengineering strategies for regenerative medicine.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Functional restoration of ex vivo model of pylorus: Co-injection of neural progenitor cells and interstitial cells of Cajal.Stem cells translational medicine · 2020Article
- BioSphincters to treat Fecal Incontinence in Nonhuman Primates.Scientific reports · 2019Article
- Stem cell therapy for faecal incontinence: Current state and future perspectives.World journal of stem cells · 2018Review
- Successful Treatment of Passive Fecal Incontinence in an Animal Model Using Engineered Biosphincters: A 3-Month Follow-Up Study.Stem cells translational medicine · 2017Article
- Regenerative medicine provides alternative strategies for the treatment of anal incontinence.International urogynecology journal · 2017Review
- Bioengineering the gut: future prospects of regenerative medicine.Nature reviews. Gastroenterology & hepatology · 2016Review
- Bioengineering functional human sphincteric and non-sphincteric gastrointestinal smooth muscle constructs.Methods (San Diego, Calif.) · 2016Article
- Bioengineered Human Pyloric Sphincters Using Autologous Smooth Muscle and Neural Progenitor Cells.Tissue engineering. Part A · 2016Article
- Successful implantation of an engineered tubular neuromuscular tissue composed of human cells and chitosan scaffold.Surgery · 2015Article
- The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues.Stem cells translational medicine · 2015Article
- Stem cell therapy for GI neuromuscular disorders.Current gastroenterology reports · 2014Review
- The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets.Biomaterials · 2014Article
- Tissue engineering in the gut: developments in neuromusculature.Gastroenterology · 2014Review
- Design strategies of biodegradable scaffolds for tissue regeneration.Biomedical engineering and computational biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Muscle replacement for patients suffering from extensive tissue loss or dysfunction is a major objective of regenerative medicine. To achieve functional status, bioengineered muscle replacement constructs require innervation. Here we describe a method to bioengineer functionally innervated gut smooth muscle constructs using neuronal progenitor cells and smooth muscle cells isolated and cultured from intestinal tissues of adult human donors. These constructs expressed markers for contractile smooth muscle, glial cells, and mature neuronal populations. The constructs responded appropriately to physiologically relevant neurotransmitters, and neural network integration was demonstrated by responses to electrical field stimulation. The ability of enteric neuroprogenitor cells to differentiate into neuronal populations provides enormous potential for functional innervation of a variety of bioengineered muscle constructs in addition to gut. Functionally innervated muscle constructs offer a regenerative medicine-based therapeutic approach for neuromuscular replacement after trauma or degenerative disorders.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.