Pharmacogenetics and coumarin dosing--recalibrating expectations.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Genotype-guided drug prescribing: a systematic review and meta-analysis of randomized control trials.British journal of clinical pharmacology · 2015
   Pooled it
2. Evaluation of a pharmacogenetic-based warfarin dosing algorithm in patients with low time in therapeutic range - study protocol for a randomized controlled trial.BMC cardiovascular disorders · 2016
   Trial
3. The influence of excessive consumption of liquorice on phenprocoumon (Marcumar®): a case report.The Journal of international medical research · 2021
   Article
4. Drug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes.Clinical pharmacokinetics · 2021
   Review
5. Determining the necessity of phenyl ring π-character in warfarin.Bioorganic & medicinal chemistry letters · 2019
   Article
6. Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort.The pharmacogenomics journal · 2019
   Article
7. Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition.Blood · 2018
   Article
8. Warfarin: The End or the End of One Size Fits All Therapy?Journal of personalized medicine · 2018
   Review
9. Personalized medicine: Genetic risk prediction of drug response.Pharmacology & therapeutics · 2017
   Review
10. Learning from biomedical linked data to suggest valid pharmacogenes.Journal of biomedical semantics · 2017
    Article
11. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.Molecular psychiatry · 2017
    Article
12. Functional Study of the Vitamin K Cycle Enzymes in Live Cells.Methods in enzymology · 2017
    Article
13. Genetics in the 21st Century: Implications for patients, consumers and citizens.F1000Research · 2017
    Article
14. Evidence and resources to implement pharmacogenetic knowledge for precision medicine.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2016
    Review
15. A systematic analysis and comparison of warfarin initiation strategies.Pharmacogenetics and genomics · 2016
    Article
16. An expanded pharmacogenomics warfarin dosing table with utility in generalised dosing guidance.Thrombosis and haemostasis · 2016
    Observational
17. The genetics of drug efficacy: opportunities and challenges.Nature reviews. Genetics · 2016
    Review
18. A Novel Admixture-Based Pharmacogenetic Approach to Refine Warfarin Dosing in Caribbean Hispanics.PloS one · 2016
    Article
19. Development of clinical decision support alerts for pharmacogenomic incidental findings from exome sequencing.Genetics in medicine : official journal of the American College of Medical Genetics · 2015
    Article
20. Pragmatic and Ethical Challenges of Incorporating the Genome into the Electronic Medical Record.Current genetic medicine reports · 2014
    Article

Corrections and comments

• Comment on
  A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon.2013
• Comment on
  A pharmacogenetic versus a clinical algorithm for warfarin dosing.2013
• Comment on
  A randomized trial of genotype-guided dosing of warfarin.2013

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as