ArticleJournal of proteome research2014
Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced Fatty liver disease.
Article in Journal of proteome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Mechanisms of Metal-Induced Hepatic Inflammation.Current environmental health reports · 2024Review
- A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans.Communications biology · 2024Article
- Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution.Nutrients · 2023Review
- Comprehensive Two-Dimensional Gas Chromatography Mass Spectrometry-Based Metabolomics.Advances in experimental medicine and biology · 2021Article
- Toxicological Risks of Renqingchangjue in Rats Evaluated byACS omega · 2020Article
- Using Multiple Analytical Platforms to Investigate the Androgen Depletion Effects on Fecal Metabolites in a Mouse Model of Systemic Lupus Erythematosus.Journal of proteome research · 2020Article
- A State-of-the-Science Review of Arsenic's Effects on Glucose Homeostasis in Experimental Models.Environmental health perspectives · 2020Review
- Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts.Oxidative medicine and cellular longevity · 2020Article
- High fat diet deteriorates the memory impairment induced by arsenic in mice: a sub chronic in vivo study.Metabolic brain disease · 2019Article
- Mechanisms of Environmental Contributions to Fatty Liver Disease.Current environmental health reports · 2019Review
- Article
- Simultaneous Quantification of Nucleosides and Nucleotides from Biological Samples.Journal of the American Society for Mass Spectrometry · 2019Article
- Global Plasma Profiling for Colorectal Cancer-Associated Volatile Organic Compounds: a Proof-of-Principle Study.Journal of chromatographic science · 2019Article
- Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.BioMed research international · 2019Article
- Elevated Arsenic Exposure Is Associated with an Increased Risk of Chronic Hepatitis B Virus Infection: NHANES (2003-2014) in U.S. Adults.Current medical science · 2018Article
- Surface fitting for calculating the second dimension retention index in comprehensive two-dimensional gas chromatography mass spectrometry.Journal of chromatography. A · 2018Article
- Chronic exposure to arsenic and high fat diet additively induced cardiotoxicity in male mice.Research in pharmaceutical sciences · 2018Article
- Article
- Linking Genes to Microbial Biogeochemical Cycling: Lessons from Arsenic.Environmental science & technology · 2017Article
- Normal-Gamma-Bernoulli Peak Detection for Analysis of Comprehensive Two-Dimensional Gas Chromatography Mass Spectrometry Data.Computational statistics & data analysis · 2017Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Arsenic is a widely distributed environmental component that is associated with a variety of cancer and non-cancer adverse health effects. Additional lifestyle factors, such as diet, contribute to the manifestation of disease. Recently, arsenic was found to increase inflammation and liver injury in a dietary model of fatty liver disease. The purpose of the present study was to investigate potential mechanisms of this diet-environment interaction via a high-throughput metabolomics approach. GC×GC-TOF MS was used to identify metabolites that were significantly increased or decreased in the livers of mice fed a Western diet (a diet high in fat and cholesterol) and co-exposed to arsenic-contaminated drinking water. The results showed that there are distinct hepatic metabolomic profiles associated with eating a high fat diet, drinking arsenic-contaminated water, and the combination of the two. Among the metabolites that were decreased when arsenic exposure was combined with a high fat diet were short-chain and medium-chain fatty acid metabolites and the anti-inflammatory amino acid, glycine. These results are consistent with the observed increase in inflammation and cell death in the livers of these mice and point to potentially novel mechanisms by which these metabolic pathways could be altered by arsenic in the context of diet-induced fatty liver disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.