ArticleMolecular metabolism2013
In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice.
Article in Molecular metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 90 citations in OpenAlex.
- Trial
- Osteocalcin carboxylation is not associated with body weight or percent fat changes during weight loss in post-menopausal women.Endocrine · 2015Trial
- Cellular signaling crosstalk between osteoporosis and diabetes: Common mechanisms and therapeutic targets (Review).Biomedical reports · 2026Review
- Osteocalcin has many tricks to get γ-carboxylated.Cell research · 2025Article
- Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice.American journal of physiology. Endocrinology and metabolism · 2024Article
- New insights into vitamin K biology with relevance to cancer.Trends in molecular medicine · 2022Review
- Osteocalcin and the physiology of danger.FEBS letters · 2022Review
- Association of famine exposure and the serum calcium level in healthy Chinese adults.Frontiers in endocrinology · 2022Article
- Decarboxylated osteocalcin, a possible drug for type 2 diabetes, triggers glucose uptake in MG63 cells.World journal of diabetes · 2021Article
- Endocrine role of bone in the regulation of energy metabolism.Bone research · 2021Review
- Glucose Metabolism in Osteoblasts in Healthy and Pathophysiological Conditions.International journal of molecular sciences · 2021Review
- The Dual Role of Vitamin K2 in "Bone-Vascular Crosstalk": Opposite Effects on Bone Loss and Vascular Calcification.Nutrients · 2021Review
- Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease.Frontiers in endocrinology · 2021Review
- Undercarboxylated osteocalcin inhibits the early differentiation of osteoclast mediated by Gprc6a.PeerJ · 2021Article
- Article
- Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation.Calcified tissue international · 2020Article
- Association between changes in bioactive osteocalcin and glucose homeostasis after biliopancreatic diversion.Endocrine · 2020Observational
- The facts of the matter: What is a hormone?PLoS genetics · 2020Article
- Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function.American journal of physiology. Endocrinology and metabolism · 2020Article
- Factors associated with osteocalcin in men with spinal cord injury: findings from the FRASCI study.Spinal cord · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Osteocalcin is a hormone produced in bones by osteoblasts and regulating energy metabolism. While osteocalcin exists in two forms, γ-carboxylated and undercarboxylated only the latter appears to function as a hormone in vivo. It has been proposed recently that osteoclasts, the bone-resorbing cells, are responsible of decarboxylating, i.e. activating osteocalcin. To address the role of osteoclasts in the maintenance of energy metabolism we analyzed mutant mouse strains harboring either an increase or a decrease in osteoclasts number. Osteoprotegerin-deficient mice that are characterized by an increase in the number of osteoclasts demonstrate an increase in serum levels of undercarboxylated osteocalcin and are significantly more glucose tolerant than WT animals. Conversely, osteoclasts ablation in mice results in a decrease in serum undercarboxylated osteocalcin levels and in reduced glucose tolerance. These results support the notion that osteoclasts are controlling glucose metabolism at least in part through the regulation of osteocalcin decarboxylation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.