ArticleMolecular metabolism2013
Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity.
Article in Molecular metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Multisystemic Consequences of Brain-Derived Neurotrophic Factor (BDNF) Haploinsufficiency in the SD-BDNFtm1sage Rat Model.International journal of molecular sciences · 2026Review
- The Role of BDNF and TrkB in the Central Control of Energy and Glucose Balance: An Update.Biomolecules · 2024Review
- Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice.Endocrinology · 2023Article
- Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain.Science advances · 2022Article
- Functional characterization and potential therapeutic avenues for variants in the NTRK2 gene causing developmental and epileptic encephalopathies.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Article
- TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits.Nature communications · 2020Article
- TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Brain-derived neurotrophic factor inhibits hyperglycemia-induced apoptosis and downregulation of synaptic plasticity-related proteins in hippocampal neurons via the PI3K/Akt pathway.International journal of molecular medicine · 2019Article
- Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice.American journal of physiology. Endocrinology and metabolism · 2018Article
- Reduced serum levels of oestradiol and brain derived neurotrophic factor in both diabetic women and HFD-feeding female mice.Endocrine · 2017Article
- Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors.PloS one · 2017Article
- Regulation of arcuate genes by developmental exposures to endocrine-disrupting compounds in female rats.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Neurotrophic factor control of satiety and body weight.Nature reviews. Neuroscience · 2016Review
- Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance.Molecular metabolism · 2015Article
- Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus.Molecular metabolism · 2015Article
- TrkB overexpression in mice buffers against memory deficits and depression-like behavior but not all anxiety- and stress-related symptoms induced by developmental exposure to methylmercury.Frontiers in behavioral neuroscience · 2014Article
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3 authors at 2 institutions in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) and its cognate receptor, TrkB (tropomyosin receptor kinase B), are widely expressed in the brain where they regulate a wide variety of biological processes, including energy homeostasis. However, the specific population(s) of TrkB-expressing neurons through which BDNF governs energy homeostasis remain(s) to be determined. Using the Cre-loxP recombination system, we deleted the mouse TrkB gene in RGS9-2-expressing cells. In this mouse mutant, TrkB expression was abolished in several hypothalamic nuclei, including arcuate nucleus, dorsomedial hypothalamus, and lateral hypothalamus. TrkB expression was also abolished in a small number of cells in other brain regions, including the cerebral cortex and striatum. The mutant animals developed hyperphagic obesity with normal energy expenditure. Despite hyperglycemia under fed conditions, these animals exhibited normal fasting blood glucose levels and normal glucose tolerance. These results suggest that BDNF regulates energy homeostasis in part through TrkB-expressing neurons in the hypothalamus.
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