ArticleMolecular metabolism2013
Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth.
Article in Molecular metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Peroxiredoxins in the Developmental Origins of Health and Disease: Insights from Maternal Under and Overnutrition - A Critical-Interpretative Scoping Review.Cell biochemistry and biophysics · 2026Review
- Early life impacts of maternal obesity: a window of opportunity to improve the health of two generations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence.Antioxidants (Basel, Switzerland) · 2022Review
- The Use of Coenzyme Q10 in Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Role of Oxidative DNA Damage and Repair in Atrial Fibrillation and Ischemic Heart Disease.International journal of molecular sciences · 2021Review
- Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis.Bioscience reports · 2020Observational
- Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020Review
- Forkhead box O3 protects the heart against paraquat-induced aging-associated phenotypes by upregulating the expression of antioxidant enzymes.Aging cell · 2019Article
- Modulation of Coenzyme QAging · 2019Article
- The Peroxidative Cleavage of Kaempferol Contributes to the Biosynthesis of the Benzenoid Moiety of Ubiquinone in Plants.The Plant cell · 2018Article
- The fetal programming of telomere biology hypothesis: an update.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Does oxidative stress shorten telomeresBiology letters · 2017Review
- Early nutrition and ageing: can we intervene?Biogerontology · 2017Review
- Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus.Scientific reports · 2016Article
- Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Coenzyme Q and Its Role in the Dietary Therapy against Aging.Molecules (Basel, Switzerland) · 2016Review
- Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth.The American journal of clinical nutrition · 2016Article
- The Role of Mitochondrial Functional Proteins in ROS Production in Ischemic Heart Diseases.Oxidative medicine and cellular longevity · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Studies in human and animals have demonstrated that nutritionally induced low birth-weight followed by rapid postnatal growth increases the risk of metabolic syndrome and cardiovascular disease. Although the mechanisms underlying such nutritional programming are not clearly defined, increased oxidative-stress leading to accelerated cellular aging has been proposed to play an important role. Using an established rodent model of low birth-weight and catch-up growth, we show here that post-weaning dietary supplementation with coenzyme Q10, a key component of the electron transport chain and a potent antioxidant rescued many of the detrimental effects of nutritional programming on cardiac aging. This included a reduction in nitrosative and oxidative-stress, telomere shortening, DNA damage, cellular senescence and apoptosis. These findings demonstrate the potential for postnatal antioxidant intervention to reverse deleterious phenotypes of developmental programming and therefore provide insight into a potential translatable therapy to prevent cardiovascular disease in at risk humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.