ArticleSchizophrenia bulletin2014
Prefrontal inefficiency is associated with polygenic risk for schizophrenia.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.Brain imaging and behavior · 2019Pooled it
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia.BMC psychiatry · 2023Article
- Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication.Translational psychiatry · 2022Article
- Article
- Global Brain Flexibility During Working Memory Is Reduced in a High-Genetic-Risk Group for Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Functional connectome-wide associations of schizophrenia polygenic risk.Molecular psychiatry · 2021Article
- Multisite schizophrenia classification by integrating structural magnetic resonance imaging data with polygenic risk score.NeuroImage. Clinical · 2021Article
- Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls.Translational psychiatry · 2020Article
- Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms.Translational psychiatry · 2020Article
- Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.JAMA psychiatry · 2019Article
- Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.Schizophrenia bulletin · 2019Article
- MRI Indices of Cortical Development in Young People With Psychotic Experiences: Influence of Genetic Risk and Persistence of Symptoms.Schizophrenia bulletin · 2019Article
- Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.Schizophrenia bulletin · 2018Article
- Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.Schizophrenia research. Cognition · 2018Article
- The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project.Schizophrenia research · 2018Article
- Polygenic risk score: use in migraine research.The journal of headache and pain · 2018Review
- Schizophrenia polygenic risk score predicts mnemonic hippocampal activity.Brain : a journal of neurology · 2018Article
- Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory.Scientific reports · 2018Article
- Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function.PloS one · 2018Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
Considering the diverse clinical presentation and likely polygenic etiology of schizophrenia, this investigation examined the effect of polygenic risk on a well-established intermediate phenotype for schizophrenia. We hypothesized that a measure of cumulative genetic risk based on additive effects of many genetic susceptibility loci for schizophrenia would predict prefrontal cortical inefficiency during working memory, a brain-based biomarker for the disorder. The present study combined imaging, genetic and behavioral data obtained by the Mind Clinical Imaging Consortium study of schizophrenia (n = 255). For each participant, we derived a polygenic risk score (PGRS), which was based on over 600 nominally significant single nucleotide polymorphisms, associated with schizophrenia in a separate discovery sample comprising 3322 schizophrenia patients and 3587 control participants. Increased polygenic risk for schizophrenia was associated with neural inefficiency in the left dorsolateral prefrontal cortex after covarying for the effects of acquisition site, diagnosis, and population stratification. We also provide additional supporting evidence for our original findings using scores based on results from the Psychiatric Genomics Consortium study. Gene ontology analysis of the PGRS highlighted genetic loci involved in brain development and several other processes possibly contributing to disease etiology. Our study permits new insights into the additive effect of hundreds of genetic susceptibility loci on a brain-based intermediate phenotype for schizophrenia. The combined impact of many common genetic variants of small effect are likely to better reveal etiologic mechanisms of the disorder than the study of single common genetic variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.