ArticleEuropean journal of applied physiology2014
Hypoxia refines plasticity of mitochondrial respiration to repeated muscle work.
Article in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Aerobic Intermittent Hypoxic Training Is Not Beneficial for Maximal Oxygen Uptake and Performance: A Systematic Review and Meta-Analysis.Scandinavian journal of medicine & science in sports · 2025Pooled it
- The Methodological Quality of Studies Investigating the Acute Effects of Exercise During Hypoxia Over the Past 40 years: A Systematic Review.Frontiers in physiology · 2022Pooled it
- Effects of Exercise Training in Hypoxia Versus Normoxia on Vascular Health.Sports medicine (Auckland, N.Z.) · 2016Pooled it
- Effect of 8-week of dietary micronutrient supplementation on gene expression in elite handball athletes.PloS one · 2020Trial
- Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Article
- Article
- Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele.Frontiers in physiology · 2022Article
- Effect of heat acclimation on metabolic adaptations induced by endurance training in soleus rat muscle.Physiological reports · 2021Article
- Comparison of Shifts in Skeletal Muscle Plasticity Parameters in Horses in Three Different Muscles, in Answer to 8 Weeks of Harness Training.Frontiers in veterinary science · 2021Article
- Endurance Is Improved in Female Rats After Living High-Training High Despite Alterations in Skeletal Muscle.Frontiers in sports and active living · 2021Article
- Concentric and Eccentric Pedaling-Type Interval Exercise on a Soft Robot for Stable Coronary Artery Disease Patients: Toward a Personalized Protocol.JMIR research protocols · 2019Article
- Cellular Aspects of Muscle Specialization Demonstrate Genotype - Phenotype Interaction Effects in Athletes.Frontiers in physiology · 2019Article
- Aerobic Capacity, Lactate Concentration, and Work Assessment During Maximum Exercise at Sea Level and High Altitude in Miners Exposed to Chronic Intermittent Hypobaric Hypoxia (3,800 m).Frontiers in physiology · 2019Article
- Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery.Frontiers in physiology · 2018Article
- Physiological Adaptations to Hypoxic vs. Normoxic Training during Intermittent Living High.Frontiers in physiology · 2017Article
- Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle.The Journal of physiology · 2016Article
- Mitochondrial function at extreme high altitude.The Journal of physiology · 2016Review
- Nitrate Intake Promotes Shift in Muscle Fiber Type Composition during Sprint Interval Training in Hypoxia.Frontiers in physiology · 2016Article
- Limitations to oxygen transport and utilization during sprint exercise in humans: evidence for a functional reserve in muscle O2 diffusing capacity.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe explored whether altered expression of factors tuning mitochondrial metabolism contributes to muscular adaptations with endurance training in the condition of lowered ambient oxygen concentration (hypoxia) and whether these adaptations relate to oxygen transfer as reflected by subsarcolemmal mitochondria and oxygen metabolism in muscle.
methodsMale volunteers completed 30 bicycle exercise sessions in normoxia or normobaric hypoxia (4,000 m above sea level) at 65% of the respective peak aerobic power output. Myoglobin content, basal oxygen consumption, and re-oxygenation rates upon reperfusion after 8 min of arterial occlusion were measured in vastus muscles by magnetic resonance spectroscopy. Biopsies from vastus lateralis muscle, collected pre and post a single exercise bout, and training, were assessed for levels of transcripts and proteins being associated with mitochondrial metabolism.
resultsHypoxia specifically lowered the training-induced expression of markers of respiratory complex II and IV (i.e. SDHA and isoform 1 of COX-4; COX4I1) and preserved fibre cross-sectional area. Concomitantly, trends (p < 0.10) were found for a hypoxia-specific reduction in the basal oxygen consumption rate, and improvements in oxygen repletion, and aerobic performance in hypoxia. Repeated exercise in hypoxia promoted the biogenesis of subsarcolemmal mitochondria and this was co-related to expression of isoform 2 of COX-4 with higher oxygen affinity after single exercise, de-oxygenation time and myoglobin content (r ≥ 0.75). Conversely, expression in COX4I1 with training correlated negatively with changes of subsarcolemmal mitochondria (r < -0.82).
conclusionHypoxia-modulated adjustments of aerobic performance with repeated muscle work are reflected by expressional adaptations within the respiratory chain and modified muscle oxygen metabolism.
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