ArticleEuropean journal of clinical nutrition2014
Effect of inflammation on handgrip strength in the non-critically ill is independent from age, gender and body composition.
Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Gingival bleeding as a predictor of handgrip strength-an observational study and a pilot randomized clinical trial.Clinical oral investigations · 2024Trial
- Inflammation Mediates Exercise Effects on Fatigue in Patients with Breast Cancer.Medicine and science in sports and exercise · 2021Trial
- Dose-Response Association Between Handgrip Strength and All-Cause Mortality Across Different Levels of Systemic Inflammation.Journal of cachexia, sarcopenia and muscle · 2026Article
- Serum trace element levels and their associations with handgrip strength: a cross-sectional study among non-diabetic older adults in Germany.GeroScience · 2026Article
- Article
- Exploratory evaluation of combined handgrip strength and Age-Adjusted Charlson Comorbidity Index for prognosis in patients with primary liver cancer undergoing hepatectomy: a single-centre pilot study.Frontiers in medicine · 2026Article
- The association of multiple built environment factors with a clinical measure of grip strength.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Article
- Handgrip strength is associated with cognitive function in older patients with stage 3-5 chronic kidney disease: results from the NHANES.Scientific reports · 2024Article
- Association of Dietary Fiber and Measures of Physical Fitness with High-Sensitivity C-Reactive Protein.Nutrients · 2024Article
- Article
- Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden.Journal of Alzheimer's disease : JAD · 2023Article
- Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature?Current heart failure reports · 2022Review
- Muscle weakness as an additional criterion for grading sarcopenia-related prognosis in patients with cancer.Cancer medicine · 2022Article
- Comparisons and Impacts of the Basic Components of Sarcopenia Definition and Their Pairwise Combinations in Gastric Cancer: A Large-Scale Study in a Chinese Population.Frontiers in nutrition · 2021Article
- Decreased Appendicular Skeletal Muscle Mass is Associated with Poor Outcomes after ST-Segment Elevation Myocardial Infarction.Journal of atherosclerosis and thrombosis · 2020Observational
- Article
- Racial differences in inflammation and outcomes of aging among kidney transplant candidates.BMC nephrology · 2019Article
- Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesWe investigated whether C-reactive protein (CRP) as indicator of acute inflammation is associated with maximal isometric handgrip strength in non-critically ill patients. SUBJECTS/
methodsHandgrip strength was measured with Jamar dynamometer in 620 hospitalized patients (56.4±15.9 years old, 52.3% men). CRP was measured with immunoturbidimetric assay. Fat free mass (FFM) was assessed by bioelectrical impedance analysis. A general linear model regression analysis corrected for confounding variables such as age, sex, FFM, body mass index, comorbidity count and diagnosis category (malignant/benign disease) was performed to test the association between elevated levels of CRP and handgrip strength.
resultsCRP was an independent predictor of grip strength (CRP: β-coefficient: -0.169, P=0.018) even after adjustment for relevant confounders. All groups with inflammation showed significant reduction in handgrip strength, corresponding to a loss of ∼1.6 kg in mild inflammation, 3.2 kg in moderate inflammation and 2.9 kg in severe inflammation compared with patients without inflammation. DISCUSSION: Our data demonstrate the independent association between inflammation and handgrip strength in non-critically ill patients. If not corrected, reduced strength may have implications for the patients' functional status and prognosis. Increasing physical activity and resistance training during convalescence are recommended.
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