Evidence map›Paper›PMID 24326393›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014

Aneurysmal remodeling in the circle of Willis after carotid occlusion in an experimental model.

Vincent M Tutino, Max Mandelbaum, Hoon Choi, Liza C Pope, Adnan Siddiqui, John Kolega, Hui Meng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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  13. Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
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  17. Successful serial imaging of the mouse cerebral arteries using conventional 3-T magnetic resonance imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vincent M Tutino1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Biomedical Engineering, Buffalo, New York, USA.
Max Mandelbaum1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Mechanical & Aerospace Engineering, Buffalo, New York, USA.
Hoon Choi1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Mechanical & Aerospace Engineering, Buffalo, New York, USA [3] Department of Neurosurgery, Buffalo, New York, USA [4] Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, USA.
Liza C Pope1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Neurosurgery, Buffalo, New York, USA.
Adnan Siddiqui1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Neurosurgery, Buffalo, New York, USA [3] Department of Radiology, Buffalo, New York, USA.
John Kolega1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Pathology and Anatomical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.
Hui Meng1] Toshiba Stroke and Vascular Research Center, University at Buffalo, Clinical and Translational Research Center, Buffalo, New York, USA [2] Department of Biomedical Engineering, Buffalo, New York, USA [3] Department of Mechanical & Aerospace Engineering, Buffalo, New York, USA [4] Department of Neurosurgery, Buffalo, New York, USA.
Toshiba (United States) · USUniversity at Buffalo, State University of New York · USSUNY Upstate Medical University · US

Funding

Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial AneurysmsR01NS064592 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MENG, HUI · 2009 to 2013
$1.7M
NINDS NIH HHS R01 NS064592NINDS NIH HHS R01NS064592
6 · The paper itself

Abstract

Carotid occlusions are associated with de novo intracranial aneurysm formation in clinical case reports, but this phenomenon is not widely studied. We performed bilateral carotid ligation (n=9) in rabbits to simulate carotid occlusion, and sham surgery (n=3) for control. Upon euthanasia (n=3 at 5 days, n=6 at 6 months post ligation, and n=3 at 5 days after sham operation), vascular corrosion casts of the circle of Willis (CoW) were created. Using scanning electron microscopy, we quantified gross morphologic, macroscopic, and microscopic changes on the endocasts and compared findings with histologic data. At 5 days, CoW arteries of ligated animals increased caliber. The posterior communicating artery (PCom) increased length and tortuosity, and the ophthalmic artery (OA) origin presented preaneurysmal bulges. At 6 months, calibers were unchanged from 5 days, PComs further increased tortuosity while presenting segmental dilations, and the OA origin and basilar terminus presented preaneurysmal bulges. This exploratory study provides evidence that flow increase after carotid occlusion produces both compensatory arterial augmentation and pathologic remodeling such as tortuosity and saccular/fusiform aneurysm. Our findings may have considerable clinical implications, as these lesser-known consequences should be considered when managing patients with carotid artery disease or choosing carotid ligation as a therapeutic option.

Indexed as

AnimalsCarotid Artery, CommonCarotid Artery DiseasesCircle of WillisDisease Models, AnimalFemaleIntracranial AneurysmMicroscopy, Electron, ScanningRabbitsSeverity of Illness Index

Identifiers

PMID24326393
PMCPMC3948116
OpenAlexW2058221353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.