ArticleAIDS (London, England)2013
The impact of age on the prognostic capacity of CD8+ T-cell activation during suppressive antiretroviral therapy.
Article in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CD4/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Trial
- Article
- Predictive value of CD8+ T cell and CD4/CD8 ratio at two years of successful ART in the risk of AIDS and non-AIDS events.EBioMedicine · 2022Article
- T-Cell Immune Dysregulation and Mortality in Women With Human Immunodeficiency Virus.The Journal of infectious diseases · 2022Article
- The role of CD38 in HIV infection.AIDS research and therapy · 2021Review
- Changes in Inflammation but Not in T-Cell Activation Precede Non-AIDS-Defining Events in a Case-Control Study of Patients on Long-term Antiretroviral Therapy.The Journal of infectious diseases · 2018Article
- Double robust and efficient estimation of a prognostic model for events in the presence of dependent censoring.Biostatistics (Oxford, England) · 2016Article
- Stimulation of PBMC and Monocyte-Derived MacrophagesFrontiers in immunology · 2016Article
- Immune Reconstitution but Persistent Activation After 48 Weeks of Antiretroviral Therapy in Youth With Pre-Therapy CD4 >350 in ATN 061.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Transcriptional Changes in CD8(+) T Cells During Antiretroviral Therapy Intensified With Raltegravir.Open forum infectious diseases · 2015Article
- Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection.The Journal of infectious diseases · 2014Article
- Factors associated with CD8+ T-cell activation in HIV-1-infected patients on long-term antiretroviral therapy.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Article
- Soluble CD163 and monocyte populations in response to antiretroviral therapy and in relationship with neuropsychological testing among HIV-infected children.Journal of virus eradicationArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo assess whether CD8 T-cell activation predicts risk of AIDS and non-AIDS morbidity during suppressive antiretroviral treatment (ART).
designPost-hoc analyses of ART-naive participants in prospective ART studies. Participants with HIV-RNA levels 200 copies/ml or less and CD8 T-cell activation data (%CD38HLA-DR) at year-1 of ART were selected to determine years 2-5 incidence of AIDS and non-AIDS events.
methodsWe censored data at time of ART interruption or virologic failure. Inverse probability of censoring-weighted logistic regression was used to correct for informative censoring.
resultsWe included 1025 participants; 82% were men, median age 38 years, pre-ART CD4 cell count 255 cells/μl, and year-1-activated CD8 T cells 24%. Of these, 752 had 5 years of follow-up; 379 remained on ART and had no confirmed plasma HIV-RNA more than 200 copies/ml. The overall probability of an AIDS or non-AIDS event in years 2-5 was estimated at 13% [95% confidence interval (CI) 10-15%] had everyone remained on suppressive ART. Higher year-1-activated CD8 T-cell percentage increased the probability of subsequent events [odds ratio 1.22 per 10% higher (95% CI 1.04-1.44)]; this effect was not significant after adjusting for age. Among those age 50 years at least (n=108 at year 1), the probability of an event in years 2-5 was 37% and the effect of CD8 T-cell activation was more apparent (odds ratio=1.42, P=0.02 unadjusted and adjusted for age).
conclusionCD8 T-cell activation is prognostic of clinical events during suppressive ART, although this association is confounded by age. The consequences of HIV-associated immune activation may be more important in patients 50 years and older.
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