ArticleHeredity2014
Cross-validation in association mapping and its relevance for the estimation of QTL parameters of complex traits.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Discrete genetic modules underlie divergent reproductive strategies in three-spined stickleback.bioRxiv : the preprint server for biology · 2025Article
- Do lower nitrogen fertilization levels require breeding of different types of cultivars in triticale?TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Exploiting genetic diversity in two European maize landraces for improving Gibberella ear rot resistance using genomic tools.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Improving the baking quality of bread wheat by genomic selection in early generations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Genotyping by Sequencing Highlights a Polygenic Resistance to Ralstonia pseudosolanacearum in Eggplant (Solanum melongena L.).International journal of molecular sciences · 2018Article
- Using genome wide association studies to identify common QTL regions in three different genetic backgrounds based on Iberian pig breed.PloS one · 2018Article
- Defeating the Warrior: genetic architecture of triticale resistance against a novel aggressive yellow rust race.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Deciphering the regulation of porcine genes influencing growth, fatness and yield-related traits through genetical genomics.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging.Neurobiology of aging · 2016Article
- Genetic control of protein content and sedimentation volume in European winter wheat cultivars.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Copy number variation of CBF-A14 at the Fr-A2 locus determines frost tolerance in winter durum wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- Potential and limits of whole genome prediction of resistance to Fusarium head blight and Septoria tritici blotch in a vast Central European elite winter wheat population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- A robust multiple-locus method for quantitative trait locus analysis of non-normally distributed multiple traits.Heredity · 2015Article
- Genetic control of plant height in European winter wheat cultivars.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Article
- Evaluation of multi-locus models for genome-wide association studies: a case study in sugar beet.Heredity · 2015Article
- Expanding Omics Resources for Improvement of Soybean Seed Composition Traits.Frontiers in plant science · 2015Review
- Adult plant development in triticale (× triticosecale wittmack) is controlled by dynamic genetic patterns of regulation.G3 (Bethesda, Md.) · 2014Article
- Mapping dynamic QTL for plant height in triticale.BMC genetics · 2014Article
- Article
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2 authors.
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Abstract
Association mapping has become a widely applied genomic approach to identify quantitative trait loci (QTL) and dissect the genetic architecture of complex traits. However, approaches to assess the quality of the obtained QTL results are lacking. We therefore evaluated the potential of cross-validation in association mapping based on a large sugar beet data set. Our results show that the proportion of the population that should be used as estimation and validation sets, respectively, depends on the size of the mapping population. Generally, a fivefold cross-validation, that is, 20% of the lines as independent validation set, appears appropriate for commonly used population sizes. The predictive power for the proportion of genotypic variance explained by QTL was overestimated by on average 38% indicating a strong bias in the estimated QTL effects. The cross-validated predictive power ranged between 4 and 50%, which are more realistic estimates of this parameter for complex traits. In addition, QTL frequency distributions can be used to assess the precision of QTL position estimates and the robustness of the detected QTL. In summary, cross-validation can be a valuable tool to assess the quality of QTL parameters in association mapping.
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