ArticleJournal of ovarian research2013
Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery.
Article in Journal of ovarian research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01344486 (Peritoneal Cavity Conditioning During Laparoscopic Surgery Decreases Postoperative Pain, Inflammatory Reaction and Postoperative Adhesions), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peritoneal Cavity Conditioning During Laparoscopic Surgery Decreases Postoperative Pain, Inflammatory Reaction and Postoperative Adhesions
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Use of mixed gas pneumoperitoneum during minimally invasive surgery: a systematic review of human and mouse modelled laparoscopic interventions.Journal of robotic surgery · 2024Pooled it
- Pooled it
- Adhesion prevention after endometriosis surgery - results of a randomized, controlled clinical trial with second-look laparoscopy.Langenbeck's archives of surgery · 2021Trial
- Five year follow-up of a randomized controlled trial on warming and humidification of insufflation gas in laparoscopic colonic surgery--impact on small bowel obstruction and oncologic outcomes.International surgery · 2015Trial
- Cellular and molecular regulation of fibrotic postoperative abdominal adhesions.American journal of physiology. Cell physiology · 2026Review
- Laparoscopic Drainage of Severe Intra-abdominal Abscesses Following Cesarean Section: A Case Report.Cureus · 2025Article
- Global recommendations on adhesion prophylaxis in gynaecological laparoscopic surgery.Facts, views & vision in ObGyn · 2024Article
- Moderate Intra-Abdominal Pressure Levels in Robot-Assisted Radical Prostatectomy Seem to Have No Negative Impact on Clinical Outcomes.Journal of clinical medicine · 2024Article
- Postoperative adhesions: are we close to finding a solution?Facts, views & vision in ObGyn · 2023Article
- Article
- Postsurgical Adhesions: Is There Any Prophylactic Strategy Really Working?Journal of clinical medicine · 2023Review
- An Overview of Postoperative Intraabdominal Adhesions and Their Role on Female Infertility: A Narrative Review.Journal of clinical medicine · 2023Review
- Chemically Modified Hyaluronic Acid for Prevention of Post-Surgical Adhesions: New Aspects of Gel Barriers Physical Profiles.Journal of clinical medicine · 2022Article
- The "Dark Side" of Pneumoperitoneum and Laparoscopy.Minimally invasive surgery · 2021Review
- Comparison of laparoscopic surgery versus traditional laparotomy for the treatment of emergency patients.The Journal of international medical research · 2020Article
- Adhesions and Anti-Adhesion Systems Highlights.Facts, views & vision in ObGyn · 2019Review
- NGynecological surgery · 2017Article
- A Prospective Randomized Experimental Study to Investigate the Eradication Rate of Endometriosis after Surgical Resection versus Aerosol Plasma Coagulation in a Rat Model.International journal of medical sciences · 2016Article
- Humidification during laparoscopic surgery: overview of the clinical benefits of using humidified gas during laparoscopic surgery.Archives of gynecology and obstetrics · 2015Review
- World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research.Fertility and sterility · 2014Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo translate the concept of full-conditioning (FC) from animal experiments to the human, and to evaluate the efficacy for adhesion prevention. FC consisted of decreasing acute inflammation by 86% CO2+ 10% N2O + 4% O2 for the pneumoperitoneum, cooling of the peritoneal cavity, humidification, heparinized rinsing solution and 5 mg of dexamethasone as demonstrated in animal models.
methodsA randomized controlled trial (RCT: NCT01344486) comparing standard laparoscopy with full conditioning together with a barrier in a 2/3 ratio in 44 women undergoing deep endometriosis surgery at KULeuven. The primary aim was reduction of adhesions. Secondary aims were CO2 resorption, postoperative pain and recovery. Randomization was performed after signing informed consent. Adhesion scoring during second look laparoscopy and pain scoring were done blindly.
resultsIn the FC group (n = 16) adhesions were completely prevented in 12/16 women whereas in the control group (n = 11) all women had severe adhesions (P < 0.0005). Also the area, density and severity of adhesions were less. (P <0.001). In the control group, severity, density and area of adhesions were strongly interrelated (P = 0.0001 for all areas) suggesting a common enhancing factor. In the FC group CO2 resorption (P < 0.001), postoperative pain (P < 0.001), and CRP concentrations (P < 0.01) were lower while clinical recovery was faster (P < 0.0001) and time to first flatus (P < 0.002) shorter. IN
conclusionThis translational research confirms in the human the efficacy of FC in reducing CO2 resorption and adhesions with in addition less postoperative pain, lower postoperative CRP concentrations and an accelerated recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.