ArticleThe Journal of infectious diseases2014
Cord blood Vγ2Vδ2 T cells provide a molecular marker for the influence of pregnancy-associated malaria on neonatal immunity.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Seasonal variation in the non-specific effects of BCG vaccination on neonatal mortality: three randomised controlled trials in Guinea-Bissau.BMJ global health · 2020Trial
- Perinatal γδ T cells: between invariance and diversity.Frontiers in immunology · 2026Review
- Article
- γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis.The Journal of experimental medicine · 2024Article
- Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis.Nature communications · 2022Article
- Observational
- Malaria and Early Life Immunity: Competence in Context.Frontiers in immunology · 2021Review
- Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Human γδ TCR Repertoires in Health and Disease.Cells · 2020Review
- The immune response to malaria in utero.Immunological reviews · 2020Review
- Emerging role of γδ T cells in vaccine-mediated protection from infectious diseases.Clinical & translational immunology · 2019Review
- In utero priming of highly functional effector T cell responses to human malaria.Science translational medicine · 2018Article
- γδ T Cells in Antimalarial Immunity: New Insights Into Their Diverse Functions in Protection and Tolerance.Frontiers in immunology · 2018Review
- Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure.Scientific reports · 2017Article
- Impact of In Utero Exposure to Malaria on Fetal T Cell Immunity.Trends in molecular medicine · 2016Review
- Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Loss and dysfunction of Vδ2⁺ γδ T cells are associated with clinical tolerance to malaria.Science translational medicine · 2014Article
- Ontogeny of Innate T Lymphocytes - Some Innate Lymphocytes are More Innate than Others.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundPlasmodium falciparum placental infection primes the fetal immune system and alters infant immunity. Mechanisms leading to these outcomes are not completely understood. We focused on Vγ2Vδ2 cells, which are part of the immune response against many pathogens, including P. falciparum. These unconventional lymphocytes respond directly to small, nonpeptidic antigens, independent of major histocompatibility complex presentation. We wondered whether placental malaria, which may increase fetal exposure to P. falciparum metabolites, triggers a response by neonatal Vγ2Vδ2 lymphocytes that can be a marker for the extent of fetal exposure to malarial antigens.
methodsCord blood mononuclear cells were collected from 15 neonates born to mothers with P. falciparum infection during pregnancy (8 with placental malaria) and 25 unexposed neonates. Vγ2Vδ2 cell phenotype, repertoire, and proliferative responses were compared between newborns exposed and those unexposed to P. falciparum.
resultsPlacental malaria-exposed neonates had increased proportions of central memory Vγ2Vδ2 cells in cord blood, with an altered Vγ2 chain repertoire ex vivo and after stimulation.
conclusionOur results suggest that placental malaria affects the phenotype and repertoire of neonatal Vγ2Vδ2 lymphocytes. Placental malaria may lower the capacity for subsequent Vγ2Vδ2 cell responses and impair the natural resistance to infectious diseases or the response to pediatric vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.