ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2014
Right ventricular to left ventricular diameter ratio at end-systole in evaluating outcomes in children with pulmonary hypertension.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- A Multitask Deep Learning Model for Pediatric Echocardiography Analysis.Circulation · 2026Article
- Atrial Fibrillation and Great Saphenous Vein Insufficiency: Exploration of Common Pathways in Hemodynamic Derangements and Systemic Inflammation.Reviews in cardiovascular medicine · 2026Review
- Current State of RV Multimodality Imaging in Pediatric Pulmonary Hypertension: Current Evidence, Knowledge Gaps, and Future Research Directions.Circulation. Cardiovascular imaging · 2026Review
- Echocardiographic Changes in Infants with Severe Congenital Diaphragmatic Hernia After Fetoscopic Endoluminal Tracheal Occlusion (FETO).Pediatric cardiology · 2026Article
- Beyond the right ventricle: assessment of the left ventricular function in pulmonary hypertension.Frontiers in medicine · 2026Review
- The Role of Imaging in Pulmonary Vascular Disease: The Clinician's Perspective.Radiologic clinics of North America · 2025Review
- Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children.Frontiers in pediatrics · 2025Article
- PDA management strategies and pulmonary hypertension in extreme preterm infants with bronchopulmonary dysplasia.Pediatric research · 2025Observational
- Ventricular Dysfunction in Patients With Congenital Diaphragmatic Hernia Who Die After Repair.Journal of pediatric surgery · 2025Article
- Biventricular responses to exercise and their relation to cardiorespiratory fitness in pediatric pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2024Article
- Early cardiac function and death, severe bronchopulmonary dysplasia and pulmonary hypertension in extremely preterm infants.Pediatric research · 2024Article
- Cardiac dysfunction in severe pediatric acute respiratory distress syndrome: the right ventricle in search of the right therapy.Frontiers in medicine · 2023Review
- Echocardiographic Assessment of Right Ventricular Function in Paediatric Heart Disease: A Practical Clinical Approach.CJC pediatric and congenital heart disease · 2022Review
- Pulmonary hypertensive crisis in children with pulmonary arterial hypertension undergoing cardiac catheterization.Pulmonary circulation · 2022Article
- Normal Echocardiographic Reference Values of the Right Ventricular to Left Ventricular Endsystolic Diameter Ratio and the Left Ventricular Endsystolic Eccentricity Index in Healthy Children and in Children With Pulmonary Hypertension.Frontiers in cardiovascular medicine · 2022Article
- A guide to echocardiographic assessment in children and adolescents with pulmonary hypertension.Cardiovascular diagnosis and therapy · 2021Review
- Prognostic biomarkers in pediatric pulmonary arterial hypertension.Cardiovascular diagnosis and therapy · 2021Review
- Pediatric Pulmonary Hypertension: Definitions, Mechanisms, Diagnosis, and Treatment.Comprehensive Physiology · 2021Article
- Article
- Pulmonary hypertension in bronchopulmonary dysplasia.Pediatric research · 2021Review
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5 authors.
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Abstract
backgroundPulmonary hypertension (PH) increases right ventricular (RV) pressure, resulting in septal shift and RV dilation. Few echocardiographic measures have been used to evaluate severity and outcomes in children with PH. The aims of this study were to compare the RV to left ventricular (LV) diameter ratio at end-systole (RV/LV ratio) in normal controls and patients with PH, to correlate the RV/LV ratio with invasive hemodynamic measures, and to evaluate its association with outcomes in children with PH.
methodsThe RV/LV ratio was compared retrospectively between 80 matched normal controls and 84 PH patients without shunts. Of the patients with PH, 49 children underwent 94 echocardiographic studies and cardiac catheterizations within 48 hours (13 patients had simultaneous measurements). The RV/LV ratio was correlated against hemodynamic measures. Kaplan-Meier curves and a Cox proportional-hazards regression model were used to assess relationships between RV/LV ratio and time until an adverse clinical event (initiation of intravenous prostacyclin therapy, atrial septostomy, death, or transplantation).
resultsRV/LV ratios were lower in controls compared with patients with PH (mean, 0.51 [95% confidence interval, 0.48-0.54] vs 1.47 [95% confidence interval, 1.25-1.70], P < .01). The RV/LV ratio correlated significantly with mean pulmonary artery pressure, systolic pulmonary artery pressure, systolic pulmonary artery pressure as a percentage of systemic pressure, and pulmonary vascular resistance index (r = 0.65 [P < .01], r = 0.6 [P < .01], r = 0.49 [P < .01], and r = 0.43 [P < .01], respectively). Twenty-two patients with PH with RV/LV ratios > 1 had adverse events within a median of 1.1 years from their earliest echocardiographic studies. Increasing RV/LV ratio was associated with an increasing hazard for a clinical event (hazard ratio, 2.49; 95% confidence interval, 1.92-3.24).
conclusionsThe RV/LV end-systolic diameter ratio can easily be obtained noninvasively in the clinical setting and can be used in the management of patients with PH. The RV/LV ratio incorporates both pathologic septal shift and RV dilation in children with PH and correlates with invasive measures of PH. An RV/LV ratio > 1 is associated with adverse clinical events.
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