ArticleEnvironmental health perspectives2014
Within- and between-child variation in repeated urinary pesticide metabolite measurements over a 1-year period.
Article in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- Concurrent associations of glyphosate, dithiocarbamate fungicides, and PFAS with body fat composition and BMI in adolescents from agricultural communities.Environmental research · 2025Article
- Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings.Toxics · 2025Article
- A Novel Approach to Integrate Human Biomonitoring Data with Model Predicted Dietary Exposures: A Crop Protection Chemical Case Study Using Lambda-Cyhalothrin.Journal of agricultural and food chemistry · 2024Article
- Factors affecting urinary organophosphate pesticide metabolite levels among Californian agricultural community members.The Science of the total environment · 2023Article
- A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides.Critical reviews in toxicology · 2022Review
- Factors Associated with Levels of Organophosphate Pesticides in Household Dust in Agricultural Communities.International journal of environmental research and public health · 2022Article
- Pyrethroid exposure among children residing in green versus non-green multi-family, low-income housing.Journal of exposure science & environmental epidemiology · 2021Article
- Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides.Journal of exposure science & environmental epidemiology · 2020Article
- Variability in urinary neonicotinoid concentrations in single-spot and first-morning void and its association with oxidative stress markers.Environment international · 2020Article
- Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring attention-deficit hyperactivity disorder and autistic traits.Environment international · 2019Article
- Temporal variability in urinary pesticide concentrations in repeated-spot and first-morning-void samples and its association with oxidative stress in healthy individuals.Environment international · 2019Article
- Biomonitoring and Nonpersistent Chemicals-Understanding and Addressing Variability and Exposure Misclassification.Current environmental health reports · 2019Review
- Intra-individual variations of organophosphate pesticide metabolite concentrations in repeatedly collected urine samples from pregnant women in Japan.Environmental health and preventive medicine · 2019Article
- Variability of urinary pesticide metabolite concentrations during pregnancy in the MARBLES Study.Environmental research · 2018Article
- Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort.Environment international · 2018Article
- Hair analysis for the biomonitoring of pesticide exposure: comparison with blood and urine in a rat model.Archives of toxicology · 2017Article
- Short-term markers of DNA damage among roofers who work with hot asphalt.Environmental health : a global access science source · 2016Article
- Within-subject Pooling of Biological Samples to Reduce Exposure Misclassification in Biomarker-based Studies.Epidemiology (Cambridge, Mass.) · 2016Article
- Organophosphate Insecticide Metabolites in Prenatal and Childhood Urine Samples and Intelligence Scores at 6 Years of Age: Results from the Mother-Child PELAGIE Cohort (France).Environmental health perspectives · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundChildren are exposed to pesticides from many sources and routes, including dietary and incidental ingestion, dermal absorption, and inhalation. Linking health outcomes to these exposures using urinary metabolites requires understanding temporal variability within subjects to avoid exposure misclassification.
objectivesWe characterized the within- and between-child variability of urinary organophosphorus and pyrethroid metabolites in 23 participants of the Children's Pesticide Exposure Study-Washington over 1 year and examined the ability of one to four spot urine samples to categorize mean exposures.
methodsEach child provided urine samples twice daily over 7- to 16-day sessions in four seasons in 2003 and 2004. Samples were analyzed for five pyrethroid and five organophosphorus (OP) metabolites. After adjusting for specific gravity, we used a customized maximum likelihood estimation linear mixed-effects model that accounted for values below the limit of detection to calculate intraclass correlation coefficients (ICC) and conducted surrogate category analyses.
resultsWithin-child variability was 2-11 times greater than between-child variability. When restricted to samples collected during a single season, ICCs were higher in the fall, winter, and spring than in summer for OPs, and higher in summer and winter for pyrethroids, indicating an increase in between-person variability relative to within-person variability during these seasons. Surrogate category analyses demonstrated that a single spot urine sample did not categorize metabolite concentrations well, and that four or more samples would be needed to categorize children into quartiles consistently.
conclusionsUrinary biomarkers of these short half-life pesticides exhibited substantial within-person variability in children observed over four seasons. Researchers investigating pesticides and health outcomes in children may need repeated biomarker measurements to derive accurate estimates of exposure and relative risks.
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